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FLASH GENE
Symbol SLC1A7 contributors: mct - updated : 13-09-2016
HGNC name solute carrier family 1 (glutamate transporter), member 7
HGNC id 10945
Location 1p32.3      Physical location : 53.552.855 - 53.608.289
Synonym name excitatory amino acid transporter 5 (retinal glutamate transporter)
Synonym symbol(s) AAAT, EAAT5
DNA
TYPE functioning gene
STRUCTURE 55.45 kb     11 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 2696 - 560 - 2005 15737648
11 - 2873 - 619 - 2005 15737648
10 - 2499 - 472 - 2005 15737648
4 - 1335 - 158 - 2005 15737648
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart     Homo sapiens
Digestiveintestine     Homo sapiens
 liver     Homo sapiens
Reproductivemale systemtestis  highly Rattus norvegicus
Respiratorylung     Homo sapiens
Visualeyeretina  specific Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal   Homo sapiens
visualeye   
cells
SystemCellPubmedSpeciesStageRna symbol
Visualbipolar cell Homo sapiens
Visualrod photoreceptor Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • eight putative transmembrane domains
  • a single potential N-linked glycosylation site in the putative large extracellular loop
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Slc1a7
    Homologene
    FAMILY sodium-dicarboxylate (SDF) symporter family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text integral membrane protein
    basic FUNCTION
  • may participate in visual processing
  • neuronal transporters (SLC1A1, SLC1A6, and SLC1A7) appear to have additional functions in regulating and processing cellular excitability
  • in retinal photoreceptors and bipolar cells, it serves as a slow transporter and as an inhibitory glutamate receptor, the latter role is due to the gating of a large chloride conductance
  • unique functional properties of SLC1A7, being a low-affinity and low-capacity glutamate transport system, with an anion channel optimized for anion conduction in the negative voltage range
  • likely significant role for SLC1A7 in mediating cone-driven DBC(depolarizing bipolar cell) light responses
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacts with the PDZ domains of DLG4
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS