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FLASH GENE

Symbol

SLC1A7

contributors: mct - updated : 13-09-2016

HGNC name	solute carrier family 1 (glutamate transporter), member 7
HGNC id	10945

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p32.3      Physical location : 53.552.855 - 53.608.289
Synonym name	excitatory amino acid transporter 5 (retinal glutamate transporter)
Synonym symbol(s)	AAAT, EAAT5

DNA

TYPE	functioning gene
STRUCTURE	55.45 kb     11 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006671 11 - 2696 NP_006662 - 560 - 2005 15737648 NM_001287595 11 - 2873 NP_001274524 - 619 - 2005 15737648 NM_001287597 10 - 2499 NP_001274526 - 472 - 2005 15737648 NM_001287596 4 - 1335 NP_001274525 - 158 - 2005 15737648

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Homo sapiens Digestive intestine         Homo sapiens   liver         Homo sapiens Reproductive male system testis     highly Rattus norvegicus Respiratory lung         Homo sapiens Visual eye retina     specific Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal     Homo sapiens visual eye

cells

System Cell Pubmed Species Stage Rna symbol Visual bipolar cell Homo sapiens Visual rod photoreceptor Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	eight putative transmembrane domains
	a single potential N-linked glycosylation site in the putative large extracellular loop

conjugated

GlycoP

HOMOLOGY

interspecies

homolog to murine Slc1a7

Homologene

FAMILY

sodium-dicarboxylate (SDF) symporter family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	plasma membrane
text	integral membrane protein

basic FUNCTION	may participate in visual processing
	neuronal transporters (SLC1A1, SLC1A6, and SLC1A7) appear to have additional functions in regulating and processing cellular excitability
	in retinal photoreceptors and bipolar cells, it serves as a slow transporter and as an inhibitory glutamate receptor, the latter role is due to the gating of a large chloride conductance
	unique functional properties of SLC1A7, being a low-affinity and low-capacity glutamate transport system, with an anion channel optimized for anion conduction in the negative voltage range
	likely significant role for SLC1A7 in mediating cone-driven DBC(depolarizing bipolar cell) light responses

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interacts with the PDZ domains of DLG4

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS