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FLASH GENE
Symbol SLC1A5 contributors: mct - updated : 02-04-2019
HGNC name solute carrier family 1 (neutral amino acid transporter), member 5
HGNC id 10943
Location 19q13.32      Physical location : 47.278.141 - 47.291.842
Synonym name
  • RD114 virus receptor,baboon M7 virus receptor
  • neutral amino acid transporter B
  • Alanine Serine Cysteine Transporter 2
  • baboon M7 virus receptor
  • sodium-dependent neutral amino acid transporter type 2
    • Synonym symbol(s) AAAT, ASCT2, ATBO, M7V1, M7VS1, R16, RDRC, FLJ31068
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 28.94 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   transcription factor
    text structure binding of NR1H4 and RXRG to the promoter stimulating ASCT2 expression in response to glutamine
    MAPPING cloned Y linked Y status provisional
    Map cen - D19S47 - D19S8 - (GYS1 ,SLC1A5 ) - D19S22 - qter
    Authors Jones (94)
    Physical map
    LOC388555 19 similar to RPRC483 LOC126052 19q13.33 TGFB-induced factor (TALE family homeobox) pseudogene LOC147920 19q13.33 similar to VPRI645 LOC390944 19 similar to 60S ribosomal protein L12 UNQ644 19q13.33 APRG644 HIF3A 19q13.33 hypoxia inducible factor 3, alpha subunit PPP5C 19q13.3 protein phosphatase 5, catalytic subunit DKFZP564K0322 LOC390945 19 similar to paraneoplastic neuronal antigen MM2 FLJ10781 19q13.33 hypothetical protein FLJ10781 KIAA1183 19q13.33 KIAA1183 protein LOC390946 19 similar to Serine/threonine protein phosphatase 5 (PP5) (Protein phosphatase T) (PP-T) (PPT) LOC390947 19 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) CALM3 19q13.3 calmodulin 3 (phosphorylase kinase, delta) PTGIR 19q13.3 prostaglandin I2 (prostacyclin) receptor (IP) GNG8 19q13.2-q13.3 guanine nucleotide binding protein (G protein), gamma 8 MGC15476 19q13.33 thymus expressed gene 3-like PRKD2 19q13.2 thymus expressed gene 3-like STRN4 19q13.2 striatin, calmodulin binding protein 4 FKRP 19q13.33 fukutin related protein SLC1A5 19q13.3 solute carrier family 1 (neutral amino acid transporter), member 5 LOC390948 19 similar to heterogeneous nuclear ribonucleoprotein M isoform a; heterogenous nuclear ribonucleoprotein M4; N-acetylglucosamine receptor 1; M4 protein; heterogenous nuclear ribonucleoprotein M AP2S1 19q13.2-q13.3 adaptor-related protein complex 2, sigma 1 subunit GRLF1 19q13.3 glucocorticoid receptor DNA binding factor 1 NPAS1 19q13.2-q13.3 neuronal PAS domain protein 1 FLJ20512 19q13.33 hypothetical protein FLJ20512 C19orf7 19q13.33 chromosome 19 open reading frame 7 SAE1 19q13.33 SUMO-1 activating enzyme subunit 1 BBC3 19q13.3-q13.4 BCL2 binding component 3 DKFZP586M1019 LOC255783 19q13.33 hypothetical protein LOC255783
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2873 - 541 - 2018 29563155
    8 - 1737 - 313 - 2018 29563155
    7 - 1927 - 339 - 2018 29563155
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
    Reproductivefemale systemovary  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductiveoocyte Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • ten transmembrane spanning segments (10TM),
  • six N terminal and cytoplasmic N and C termini
  • two N-glycosylation sites (N163 and N212) located in the large extracellular loop
    • HOMOLOGY
    Homologene
    FAMILY solute carrier family 1, glutamate/neutral amino acid
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • Na+ (and K+) dependent glutamate transporter, accepting as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated amino acids, anionic amino acids, and cationic amino acids
  • plays a key role in Gln transport controlling lung cancer cells metabolism, growth, and survival
  • ERVW1 and its receptor SLC1A45 are present in human gametes and localization and temporal appearance is consistent with a possible role in fusion between oocyte and sperm
  • is an important transporter of glutamine various cancer cells
  • N-linked glycosylation of SLC1A5 (ASCT2) transporter is critical for trafficking to membrane
  • involved in balancing the intracellular amino acid pool
  • plasma membrane transporter, responsible for mediating Na- dependent antiport of neutral amino acids
  • is responsible for the uptake of glutamine into cells, a major source of cellular energy and a key regulator of mammalian target of rapamycin (MTOR) activation
  • plays an important role in esophageal cancer
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
  • Cys is a potent competitive inhibitor of SLC1A5 but is not a substrate
    • protein
  • GJA1-mediated GJB1 and SLC1A5 interaction play important functional roles in trophoblast cell fusion
  • interactions of SLC5A1 with the scaffold protein PDZK1
  • SLC6A4 associates with SLC1A5, co-expressed with SLC6A4 in serotonergic neurons and involved in the transport of small neutral amino acids across the plasma membrane
  • PPARD directly regulated neutral amino acid transporter SLC1A5 and SLC2A1 gene transcription, leading to uptake of glucose and amino acid, activation of MTOR signaling and tumor progression
  • membrane-trafficked cargo molecule, sorted through a direct interaction with the PDZ domain of sorting nexin 27 (SNX27)
  • SLC1A5, a key glutamine transporter, is a novel TEAD1 target gene
  • TEAD1 promotes vascular smooth muscle cells (VSMCs) proliferation via transcriptional induction of SLC1A5, thereby activating MTOR signaling and promoting neointima formation
  • critical for activation of MTOR activity by amino acids, and is a transcriptional target of MYC
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in esophageal cancer
    tumoral     --over  
    significantly in colorectal cancer compared with normal mucosa tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveoesophagus
    inhibition of esophageal cancer growth by targeting SLC1A5 could, therefore, be used as a preoperative therapy for esophageal cancer
    cancerdigestivecolon
    SLC1A5 could be a novel therapeutic target against KRAS-mutant colorectal cancer
    ANIMAL & CELL MODELS