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FLASH GENE
Symbol SLC1A3 contributors: mct - updated : 22-05-2013
HGNC name solute carrier family 1 (glial high affinity glutamate transporter), member 3
HGNC id 10941
Corresponding disease
EA6 episodic ataxia, type 6
Location 5p13.2      Physical location : 36.606.456 - 36.688.434
Synonym name
  • glutamate/aspartate transporter
  • high-affinity neuronal glutamate transporter
  • sodium-dependent glutamate/aspartate transporter 1
  • excitatory amino acid transporter 1
  • glial high affinity glutamate transporter
  • Synonym symbol(s) EAAT1, GLAST, FLJ25094, GLAST1
    DNA
    TYPE functioning gene
    STRUCTURE 81.98 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure
  • promoter comprises the 2.3 kb region immediately flanking the prime-end of the SLC1A3 gene
  • species-specific function of the SLC1A3 3prime-UTR in constitutive and regulated SLC1A3 expression
  • MAPPING cloned Y linked   status confirmed
    Physical map
    LOC389280 5 similar to SMA3 protein LOC389281 5 similar to bA110H4.2 (similar to membrane protein) RAI14 5p13.3-p13.2 retinoic acid induced 14 FLJ25439 5p13.3 hypothetical protein FLJ25439 RAD1 5p13.3-p13.2 RAD1 homolog (S. pombe) BRIX 5p13.3 BRIX LOC134218 5p13.3 hypothetical protein LOC134218 AGXT2 5p13 alanine-glyoxylate aminotransferase 2 PRLR 5p14-p13.3 prolactin receptor LOC389282 5 similar to RIKEN cDNA C230086A09 gene FLJ23577 5p13.2 hypothetical protein FLJ23577 IL7R 5p13 interleukin 7 receptor MGC26610 5p13.2 hypothetical protein MGC26610 FLJ34658 5p13.2 hypothetical protein FLJ34658 LOC167127 5p13.2 hypothetical protein LOC167127 DKFZp434H2226 5p13.2 hypothetical protein DKFZp434H2226 SKP2 5p13 S-phase kinase-associated protein 2 (p45) FLJ30596 5p13.2 hypothetical protein FLJ30596 FLJ25422 5p13.2 hypothetical protein FLJ25422 SLC1A3 5p13 solute carrier family 1 (glial high affinity glutamate transporter), member 3 LOC345513 5p13.2 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) IDN3 5p13.2 IDN3 protein LOC391777 5 similar to ribosomal protein S4, X-linked FLJ13231 5p13.2 hypothetical protein FLJ13231 LOC389283 5 LOC389283 OFD1P1 5p13 oral-facial-digital syndrome 1, pseudogene 1 NUP155 5p13 nucleoporin 155kDa FLJ10233 5p13.2 hypothetical protein FLJ10233 GDNF 5p13-p12 glial cell derived neurotrophic factor FLJ39155 5p13.2 hypothetical protein FLJ39155 LIFR 5p13-p12 leukemia inhibitory factor receptor LOC253254 5p13.2 hypothetical LOC253254 OSMR 5p13.2 oncostatin M receptor KIAA1999 MGC39830 5p13.2 hypothetical protein MGC39830
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 4188 - 542 - 1995 7698014
    2 - 1376 - 65 - 1995 7698014
    8 - 3670 - 497 - 1995 7698014
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Nervousbrainforebraincerebral cortex highly
     nervecranial nerve  highly
     spinal cord    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousastrocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • ten transmembrane spanning segments (mutations in transmembrane domains 5 and 7 affect the substrate-activated anion), and some AAs of TM5 take part in the transport pathway during the transport cycle
  • six N terminal and cytoplasmic N and C termini
  • HOMOLOGY
    Homologene
    FAMILY
  • sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family
  • SLC1A3 subfamily
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,membrane
    text
  • is expressed in myocardial mitochondria, and functions in the malate/aspartate shuttle
  • basic FUNCTION
  • Na+ (and K+) dependent glutamate transporter, involved in development and neonatal hypoxic-ischemic damage
  • glial high affinity glutamate/aspartate transporter in the cerebellum
  • playing an essential role for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft
  • may be playing a role in myocardial glutamate metabolism
  • playing a necessary role for brain development through regulation of extracellular glutamate concentration
  • major role, both in protecting the synapse from exposure to excess extracellular glutamate and in attenuating hearing loss due to acoustic overstimulation
  • allows significant passive and active water transport, which suggests that water permeation through glutamate transporters may play an important role in glial cell homoeostasis
  • does not only mediate secondary-active glutamate transport, but also functions as an ion channel
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EA6
    related resource MITOP database
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in motor neuron disease
    constitutional     --low  
    may be an adaptive response to neuronal death or it may be a causative event contributing to neuronal death
    Susceptibility
    Variant & Polymorphism
    Candidate gene its expression is exceptionally rare in non-neoplastic choroid plexus and is a helpful diagnostic tool in choroid plexus tumors
    Marker
    Therapy target
    ANIMAL & CELL MODELS