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FLASH GENE
Symbol SLC1A1 contributors: mct/npt/shn - updated : 17-04-2016
HGNC name solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
HGNC id 10939
Location 9p24.2      Physical location : 4.490.426 - 4.587.469
Synonym name
  • excitatory amino acid carrier 1
  • excitatory amino acid transporter 3
  • neuronal and epithelial glutamate transporter
  • sodium-dependent glutamate/aspartate transporter 3
  • solute carrier family 1 member 1
  • Synonym symbol(s) EAAC1, EAAT3
    DNA
    TYPE functioning gene
    STRUCTURE 97.03 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map pter - D9S1813 - D9S1792 - SLC1A1 - D9S1686 - D9S1810 - cen
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 3730 57 524 - Shashidharan (1994)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainforebraincerebral cortex highly Homo sapiens
     brainforebraincerebral cortexfrontal cortexspecific Homo sapiens
     brainlimbic systemhippocampus lowly Homo sapiens
     brainhindbraincerebellum lowly Homo sapiens
     brain   highly Homo sapiens
     ganglia   moderately Homo sapiens
    Reproductivefemale systemplacenta  moderately Homo sapiens
    Respiratorylung   moderately Homo sapiens
    Urinarykidneytubuleconvoluted tubuleproximal tubule  Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 10 transmembrane spanning segments (10TM)
  • six N terminal and cytoplasmic N and C termini
  • HOMOLOGY
    interspecies ortholog to Slc1a1, Mus musculus
    ortholog to Slc1a1, Rattus norvegicus
    ortholog to SLC1A1, Pan troglodytes
    Homologene
    FAMILY
  • sodium : dicarboxylate (SDF) symporter (tc 2.a.23) family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    text
  • expressed in neuronal and glial mitochondria where it participates in glutamate-stimulated ATP production
  • basic FUNCTION
  • glial high affinity glutamate transporter, Na and K dependent
  • play an essential role in regulating temporal and spatial glutamate concentration in the synaptic cleft
  • playing an essential role for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft
  • acting as a symport by cotransporting sodium
  • important for zinc homeostasis and neuronal antioxidant function under ischemic conditions
  • neuronal transporters (SLC1A1, SLC1A6, and SLC1A7) appear to have additional functions in regulating and processing cellular excitability
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text a neuronal glutamate and cysteine transporter
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • GTRAP3-18
  • PKCalpha
  • physical interaction between SLC1A1 and SLC8A1 both in neuronal and glial mitochondria, and SLC8A1 is an essential modulator of this glutamate transporter
  • KL is a novel, powerful regulator of the excitatory amino acid transporters SLC1A1, SLC1A6
  • both, STK39 and OXSR1 are negative regulators of SLC1A1 activity
  • CAV1 is a powerful negative regulator of the excitatory glutamate transporters SLC1A1, SLC1A2, SLC1A3, SLC1A6
  • SORCS2 acts as sorting receptor that sustains cell surface expression of the neuronal amino acid transporter SLC1A1 to facilitate import of cysteine, required for synthesis of the reactive oxygen species scavenger glutathione
  • cell & other
    REGULATION
    activated by protein kinase C, PKC
    Other its trafficking on and off the plasma membrane is regulated by CAV1
    regulation by expression and activation of delta-opioid receptor
    ASSOCIATED DISORDERS
    corresponding disease(s)
    related resource MITOP database
    Susceptibility to Obsessive-Compulsive Disorder
    Variant & Polymorphism other polymorphism increasing the risk of obsessive-compulsive disorder
    Candidate gene
    Marker
    Therapy target
  • Treatment of the EAAC1(-/-) mice with N-acetyl cysteine restored neuronal glutathione concentrations, normalized basal zinc levels, reduced ischemia-induced zinc translocation, superoxide production, and neuron death
  • ANIMAL & CELL MODELS
  • EAAC1(-/-) mice subjected to transient cerebral ischemia exhibited twice as much hippocampal neuronal death, elevated vesicular and cytosolic zinc concentrations in hippocampal CA1 neurons and an increased zinc translocation to postsynaptic neurons after ischemia