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FLASH GENE

Symbol

SLC17A9

contributors: mct/pgu - updated : 08-09-2010

HGNC name	solute carrier family 17, member 9
HGNC id	16192

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	20q13.33      Physical location : 61.583.998 - 61.599.941
Synonym name	chromosome 20 open reading frame 59
	vesicular nucleotide transporter SLC17A9
Synonym symbol(s)	FLJ23412, C20orf59

DNA

TYPE	functioning gene
STRUCTURE	15.95 kb     13 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_022082 13 - 2612 NP_071365 47.3 436 - 2008 18375752

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain limbic system hippocampus   highly   brain forebrain cerebral cortex   highly   brain diencephalon thalamus   highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central     highly Nervous peripherous     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

12 putative transmembrane domains

HOMOLOGY

Homologene

FAMILY

major facilitator superfamily

CATEGORY

transport

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane

basic FUNCTION	vesicular nucleotide transporter and should lead to the elucidation of the molecular mechanism of ATP secretion in purinergic signal transmission
	SLC17A9-dependent vesicular exocytosis in ATP release and T cell activation
	involved in vesicular storage of ATP and exocytosis of ATP, and plays a critical role in both vesicular exocytosis of ATP and TCR signaling during T cell activation
	contributed to ATP vesicle formation and regulated ATP release
	existence of an SLC17A9-dependent ATP-enriched vesicular pool in biliary epithelium that undergoes regulated exocytosis to initiate purinergic signaling

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS