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FLASH GENE
Symbol SLC17A8 contributors: mct - updated : 02-04-2008
HGNC name solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8
HGNC id 20151
Corresponding disease
DFNA25 neurosensory deafness 25
Location 12q23.1      Physical location : 100.750.856 - 100.815.836
Synonym name
  • vesicular glutamate transporter 3
  • Synonym symbol(s) VGLUT3
    DNA
    TYPE functioning gene
    STRUCTURE 64.00 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 3838 - 589 - Almqvist (2007)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus    
    Nervousbrainhindbrainmedulla oblongata  
     braindiencephalonamygdala  
     gangliasensory gangliadorsal root   Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 8 membrane-spanning segments and
  • a long C terminus, similar to SLC17A7 and SLC17A6
  • HOMOLOGY
    intraspecies homolog to SLC17A7,SLC17A6
    Homologene
    FAMILY
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells
  • functioning as a vesicular glutamate transporter
  • specifically involved in a functional facet of cholinergic interneurons, acetylcholine release
  • responsible for vesicular glutamate storage and exocytotic glutamate release in neurons and astrocytes
  • both SLC17A8 and the cytosolic concentration of glutamate are key limiting factors in regulating the Ca2+-dependent release of glutamate from astrocytes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DFNA25
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    induced a hypocholinergic phenotype
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target appealing pharmacological target for selectively and moderately reducing striatal cholinergic tone
    ANIMAL & CELL MODELS