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FLASH GENE
Symbol SLC17A7 contributors: mct - updated : 05-10-2018
HGNC name solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7
HGNC id 16704
Location 19q13      Physical location : 49.932.655 - 49.944.808
Synonym name
  • vesicle-bound glutamate transporter
  • brain-specific Na-dependent inorganic phosphate cotransporter
  • Synonym symbol(s) BNPI, VGLUT1
    DNA
    TYPE functioning gene
    STRUCTURE 12.00 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbrainmedulla oblongata lowly
     brainbasal nuclei  lowly
     brainhindbraincerebellum highly
     braindiencephalonhypothalamus highly
     gangliasensory gangliadorsal root   Homo sapiens
    Reproductivefemale systemovary   
    Visualeye    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve putative transmembrane segments (12TM)
  • cytosolic N and C termini
  • a motif in the fourth TM domain charcacteristic of the ACS family
  • HOMOLOGY
    interspecies homolog to Drosophila cg3961
    homolog to C.elegans y65b4bl.5
    Homologene
    FAMILY
  • solute carrier family 17
  • distinct class within the Na+/pi cotransporter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • synaptic vesicles
  • membrane associated
  • basic FUNCTION
  • phosphate transport protein, Na+ dependent, playing an unanticipated role in membrane trafficking at the nerve terminal
  • vesicular glutamate transporter, regulating the efficacy of neurotransmission
  • responsible for vesicular glutamate storage and exocytotic glutamate release in neurons and astrocytes
  • synapse-related genes showed significant age-related expression change (DLG4, GAP43, SLC17A7)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with VGLUT2 during development, at multiples synapses
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS