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FLASH GENE
Symbol SLC17A1 contributors: mct/ - updated : 19-01-2011
HGNC name solute carrier family 17 (sodium phosphate), member 1
HGNC id 10929
Location 6p22.2      Physical location : 25.783.126 - 25.832.287
Synonym name
  • sodium phosphate transporter
  • sodium/phosphate type I cotransporter
  • renal sodium-phosphate transport protein 1
  • solute carrier family 17 (vesicular glutamate transporter), member 1
  • Synonym symbol(s) NAPI1, NPT1, MGC126794, MGC126796, NAPI-1, NPT-1
    DNA
    TYPE functioning gene
    STRUCTURE 49.16 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure
  • has a TATA-like box but no CAAT box, and the transcription start site was identified by primer extension and 5'-rapid amplification of cDNA ends
  • expression transcriptionally regulated
  • MAPPING cloned Y linked N status confirmed
    Physical map
    LRRC16 6p22.1 leucine rich repeat containing 16 SCGN 6p22.3-p22.1 secretagogin, EF-hand calcium binding protein HIST1H2AA 6p21 histone 1, H2aa HIST1H2BA 6p21 histone 1, H2ba SLC17A4 6p22-p21.3 solute carrier family 17 (sodium phosphate), member 4 SLC17A1 6p22-p21.3 solute carrier family 17 (sodium phosphate), member 1 SLC17A3 6p21.3 solute carrier family 17 (sodium phosphate), member 3 HIST1H2APS2 6p22 histone 1, H2a, pseudogene 2 SLC17A2 6p21.3 solute carrier family 17 (sodium phosphate), member 2 TRIM38 6p21.3 tripartite motif-containing 38 HIST1H1PS2 6p21.3 histone 1, H1, pseudogene 2 HIST1H1A 6p22-p21 histone 1, H1a HIST1H3A 6p21.3 histone 1, H3a HIST1H4A 6p21.3 histone 1, H4a HIST1H4B 6p21.3 histone 1, H4b HIST1H3B 6p21.3 histone 1, H3b HIST1H2AB 6p21.3 histone 1, H2ab
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 1859 - 467 - 2003 14531806
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Urinarykidneytubuleconvoluted tubuleproximal tubule  Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve putative transmembrane segments (12TM) with cytosolic N and C termini
  • a motif in the fourth TM domain charcacteristic of the ACS family
  • HOMOLOGY
    intraspecies paralog to SLC17A2, SLC17A3, SLC17A4
    Homologene
    FAMILY
  • major facilitator superfamily
  • sodium/anion cotransporter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • phosphate transport protein, Na+ dependent
  • cotransporters in the apical membrane of renal proximal tubular cells play a major role in the maintenance of P(i) homeostasis
  • urate transporter, which mediates the transmembrane cotransport of Na+/Pi in oocytes
  • Cl&
  • 8722;-dependent polyspecific anion exporter involved in urate excretion under physiological conditions
  • polyspecific anion transporter with substrate specificity distinct from those of other SLC17 members
  • transports aspirin and salicylate, participating in the renal excretion of urate and nonsteroidal anti-inflammatory drugs
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to gout
    Variant & Polymorphism other
  • polymorphisms are associated with the development of gout
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS