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FLASH GENE
Symbol SLC16A8 contributors: mct/npt - updated : 24-03-2010
HGNC name solute carrier family 16, member 8 (monocarboxylic acid transporter 3)
HGNC id 16270
Location 22q13.1      Physical location : 38.474.144 - 38.479.170
Synonym name
  • monocarboxylate transporter 3
  • solute carrier 16 (monocarboxylic acid transporters), member 8
  • Synonym symbol(s) MCT3, REMP
    DNA
    TYPE functioning gene
    STRUCTURE 5.03 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LGALS2 22q13.1 lectin, galactoside-binding, soluble, 2 (galectin 2) GGA1 22q13.31 golgi associated, gamma adaptin ear containing, ARF binding protein 1 SH3BP1 22q13.1 SH3-domain binding protein 1 PLP LGALS1 22q13.1 lectin, galactoside-binding, soluble, 1 (galectin 1) MGC3731 22q13.1 hypothetical protein MGC3731 HRIHFB2122 22q13.1 hypothetical protein MGC3731 H1F0 22q13.1 H1 histone family, member 0 GCAT 22q13.1 glycine C-acetyltransferase (2-amino-3-ketobutyrate coenzyme A ligase) GALR3 22q13.1 galanin receptor 3 LOC129138 22q13.1 hypothetical protein BC014641 EIF3S6IP 22q12-q13 eukaryotic translation initiation factor 3, subunit 6 interacting protein MIRAB13 22q13.1-q13.2 molecule interacting with Rab13 C22orf23 22q13.1 chromosome 22 open reading frame 23 POLR2F 22q13.1 polymerase (RNA) II (DNA directed) polypeptide F SOX10 22q13.1 SRY (sex determining region Y)-box 10 LOC388899 22 LOC388899 PRKCABP 22q13.1 protein kinase C, alpha binding protein SLC16A8 22q12.3-q13.2 solute carrier 16 (monocarboxylic acid transporters), member 8 FLJ22582 22q13.1 hypothetical protein FLJ22582 PLA2G6 22q13.1-q13.32 phospholipase A2, group VI (cytosolic, calcium-independent) MAFF 22q13.1 v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) C22orf5 22q12 chromosome 22 open reading frame 5 CSNK1E 22q13.1 casein kinase 1, epsilon KCNJ4 22q13.1 potassium inwardly-rectifying channel, subfamily J, member 4 KDELR3 22q13.1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 DDX17 22q13.1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 DMC1 22q13.1 DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)
    regionally located between markers WI11639 and SGC30687
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1913 - 504 - Wilson (2005)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Visualeye    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/liningretinal pigment epithelium (RPE)  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Slc16a8
    homolog to rattus Slc16a8
    intraspecies homolog to SLC16A3
    Homologene
    FAMILY
  • major facilitator superfamily
  • monocarboxylate porter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text preferentially expressed in the basolateral membrane of the retinal pigment epithelium (Daniele 2008)
    basic FUNCTION
  • proton-coupled transporter
  • transport of lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate
  • proton-coupled monocarboxylate transporter, critically positioned to facilitate transport of lactate and H(+) out of the retina and could therefore play a role in pH and ion homeostasis of the outer retina (Daniele 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text small molecule transport
    PATHWAY
    metabolism monocarbon
    signaling
    a component
  • forms a heteromeric complex with the accessory protein CD147 (Daniele 2008)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    leads to a potentially reversible decrease in subretinal space pH, thereby reducing the magnitude of the light suppressible photoreceptor current (Daniele 2008)
    constitutional germinal mutation      
    associated with severe psychomotor retardation and triiodothyronine T3 levels (Visser 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS