Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SLC16A7 contributors: npt/ - updated : 10-09-2009
HGNC name solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
HGNC id 10928
Location 12q14.1      Physical location : 60.083.125 - 60.175.407
Synonym name
  • solute carrier family 16 (monocarboxylic acid transporters), member 7
  • monocarboxylate transporter 2
  • Synonym symbol(s) MCT2
    DNA
    TYPE functioning gene
    STRUCTURE 92.28 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    DKFZP586D0919 12q13.2 hepatocellularcarcinoma-associated antigen HCA557a TSFM 12q13-q14 Ts translation elongation factor, mitochondrial AVIL 12q13.13 advillin CTDSP2 12q13-q15 . CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 KUB3 12q13.2 Ku70-binding protein 3 LOC338805 12q13.2 similar to heat shock 70kD protein binding protein; progesterone receptor-associated p48 protein; putative tumor suppressor ST13; Hsp70-interacting protein LOC256176 12q13.2 hypothetical LOC256176 FLJ90440 12q13.2 hypothetical protein FLJ90440 LOC390334 12 hypothetical gene supported by NM_152636 SLC16A7 12q13 solute carrier family 16 (monocarboxylic acid transporters), member 7 LOC390335 12 similar to poly(A) binding protein, cytoplasmic 4 isoform 2 PGBD3P1 12q13.12 piggyBac transposable element derived 3 pseudogene 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 3575 52.1 478 - Lin (1998)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
     stomach    
    Nervousbrain   highly
    Urinarykidneytubule   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularexocrine 
    Nervouscentralwhite matter  
    Nervouscentralgray matter  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestivehepatocyte
    Digestiveparietal
    Nervousastrocyte
    Nervousneuron
    cell lineage
    cell lines widely in cancer cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve transmembrane spanning segments
  • a cytoplasmic loop between TM6 and TM7
  • HOMOLOGY
    Homologene
    FAMILY
  • major facilitator superfamily
  • sodium:neurotransmitter symporter (SNF) family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text preferential postsynaptic localization of its synaptic expression (Chiry 2008)
    basic FUNCTION
  • high affinity pyruvate transporter
  • involved in the transport of lactate, pyruvate and ketone bodies (Chiry 2008)
  • having a putative role in adjustment of energy supply to levels of activity (Chiry 2008)
  • having a role in the transport of gamma-hydroxybutyric acid in mammalian cells (Wang 2007)
  • catalyse the proton-linked transport of metabolically important monocarboxylates such as lactate, pyruvate and ketone bodies (Halestrap 2004)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text monocarboxylate transport
    PATHWAY
    metabolism monocarbon
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • proton linked
  • protein
  • CD147 (BSG)
  • interaction between EMB and SLC16A7 (ancillary protein EMB required to maintain the catalytic activity of SLC16A7 as well as for their translocation to the plasma membrane)(Wilson 2005)
  • cell & other
    REGULATION
    activated by estradiol
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS