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FLASH GENE
Symbol SLC16A3 contributors: mct/npt - updated : 10-09-2009
HGNC name solute carrier family 16 (monocarboxylic acid transporters), member 3
HGNC id 10924
Location 17q25.3      Physical location : 80.186.292 - 80.197.368
Synonym name monocarboxylate transporter 3
Synonym symbol(s) MCT3, MCT4, MGC138472, MGC138474
DNA
TYPE functioning gene
STRUCTURE 11.08 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
MGC13090 17q25.3 hypothetical protein MGC13090 MAFG 17q25 v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian) LOC92659 17q25.3 hypothetical protein BC009233 PYCR1 17q25.3 pyrroline-5-carboxylate reductase 1 LOC255275 17q25.3 similar to myeloid-associated differentiation marker LOC147111 17q25.3 hypothetical protein LOC147111 ASPSCR1 17q25 alveolar soft part sarcoma chromosome region, candidate 1 STRA13 17q25.3 stimulated by retinoic acid 13 MGC20806 17q25.3 hypothetical protein MGC20806 RAC3 10q25.3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) DCXR 17q25.3 dicarbonyl/L-xylulose reductase GPS1 17q25.3 G protein pathway suppressor 1 PP3111 17q25.3 PP3111 protein FASN 17q25 fatty acid synthase FLJ23754 17q25.3 hypothetical protein FLJ23754 LOC284001 17q25.3 hypothetical protein LOC284001 SLC16A3 17q25 solute carrier family 16 (monocarboxylic acid transporters), member 3 LOC388434 17 LOC388434 CSNK1D 17q25.2-q25.3 casein kinase 1, delta CD7 17q25.2-q25.3 CD7 antigen (p41) SECTM1 17q25.2-q25.3 secreted and transmembrane 1 GPR14 17q25.3 G protein-coupled receptor 14 FLJ22222 17q25.3 hypothetical protein FLJ22222
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 2054 - 465 - Wang (2007)
5 - 2033 - 465 - Wang (2007)
5 - 2035 - 465 - Wang (2007)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/liningretinal pigment epithelium (RPE)  
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • comprising twelve transmembrane spanning segments
  • a cytoplasmic loop between TM6 and TM7
  • HOMOLOGY
    Homologene
    FAMILY
  • major facilitator superfamily
  • monocarboxylate porter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • catalyzing the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine
  • having a role in the transport of gamma-hydroxybutyric acid in mammalian cells (Wang 2007)
  • catalyse the proton-linked transport of metabolically important monocarboxylates such as lactate, pyruvate and ketone bodies (Halestrap 2004)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text monocarboxylate transport
    PATHWAY
    metabolism monocarbon
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • proton linked
  • protein
  • CD147
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS