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FLASH GENE
Symbol SLC16A10 contributors: mct - updated : 24-03-2010
HGNC name solute carrier family 16, member 10 (aromatic amino acid transporter)
HGNC id 17027
Location 6q21      Physical location : 111.408.780 - 111.544.604
Synonym name
  • T-type aminoacid transporter 1
  • solute carrier family 16 (monocarboxylic acid transporters), member 10
  • aromatic amino acid transporter 1
  • monocarboxylate transporter 10
  • Synonym symbol(s) TAT1, PRO0813, MCT10
    DNA
    TYPE functioning gene
    STRUCTURE 135.41 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D6S447 - D6S404 - SLC16A10 - D6S302 - D6S303 - D6S287 - D6S1712 - D6S407 - D6S262 - D6S413 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 2918 55 515 - 2008 18337592
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
     thymus   highly Homo sapiens
    Cardiovascularheart   highly Homo sapiens
    Endocrinepancreas   highly Homo sapiens
    Lymphoid/Immunespleen   highly Homo sapiens
    Reproductivefemale systemplacenta  highly Homo sapiens
     male systemprostate  highly Homo sapiens
    Urinarykidney   highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text placenta, liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve transmembrane spanning segments
  • a cytoplasmic loop between TM6 and TM7
  • HOMOLOGY
    interspecies homolog to rattus Tat1
    intraspecies homolog to H+ monocarboxylate transporter
    homolog to XPCT
    Homologene
    FAMILY
  • major facilitator superfamily
  • monocarboxylate porter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • coexist with SLC7A8 in the basolateral membrane of the renal proximal tubules
  • basic FUNCTION
  • catalyzing the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched chain oxo acids derived from oleucine, valine and isoleucine
  • contribute to the renal reabsorption of aromatic amino acids in the basolateral domain of epithelial proximal tubule cells
  • play essential roles in the reabsorption of aromatic amino acids from the epithelial cells to the blood stream in the kidney
  • involved in the bidirectional transport of aromatic AAs and iodothyronines (preferentially transports T3 even more effectively than does SLC16A2)
  • facilitates both cellular uptake and efflux of T(4) and T(3) thyroid hormones, and is at least as active a thyroid hormone transporter as SLC16A2, and both transporters facilitate iodothyronine uptake as well as efflux
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text transporter for aromatic aminoacids, monocarboxylate transporter
    PATHWAY
    metabolism monocarbon
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • proton linked
  • protein
  • CD147
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene possibly involved in blue diaper syndrome
    Marker
    Therapy target
    ANIMAL & CELL MODELS