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FLASH GENE
Symbol SLC16A1 contributors: mct - updated : 19-03-2010
HGNC name solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
HGNC id 10922
Corresponding disease
HHF7 hyperinsulinemic hypoglycemia, familial, 7
MCTD monocarboxylic acid transporter deficiency
Location 1p13.2      Physical location : 113.454.471 - 113.498.975
Synonym name
  • monocarboxylate transporter 1
  • solute carrier family 16 (monocarboxylic acid transporters), member 1
  • Synonym symbol(s) MCT1, FLJ36745, MCT, MGC44475
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 44.51 kb     5 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site   transcription factor
    text structure PKC and AP2 binding sites in the promoter
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC55924 1pter-q31.3 hypothetical protein LOC55924 DDX20 1p21.1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 KCND3 1p13.2 potassium voltage-gated channel, Shal-related subfamily, member 3 AF357532 1q12 thioredoxin 1 pseudogene 5 DKFZp547A023 1p13.2 hypothetical protein DKFZp547A023 WNT2B 1p13 wingless-type MMTV integration site family, member 2B ST7L 1p12 suppression of tumorigenicity 7 like CAPZA1 1p13.1 capping protein (actin filament) muscle Z-line, alpha 1 MRPL53P1 1p13.2 capping protein (actin filament) muscle Z-line, alpha 1 MOV10 1p13.1 Mov10, Moloney leukemia virus 10, homolog (mouse) ARHC 1p21-p13 ras homolog gene family, member C LOC284467 1p13.1 TAFA3 MGC19531 1p13.1 hypothetical protein MGC19531 LOC128322 1p13.1 similar to Nuclear transport factor 2 (NTF-2) (Placental protein 15) (PP15) LOC388666 1 hypothetical gene supported by AK093435 SLC16A1 1p13.2-p12 solute carrier family 16 (monocarboxylic acid transporters), member 1 LRIG2 1p13.1 leucine-rich repeats and immunoglobulin-like domains 2 RPS19P2 1p13.1 ribosomal protein S19 pseudogene 2 MAGI-3 1p12-p11.2 membrane-associated guanylate kinase-related (MAGI-3) PHTF1 1p13-p11 putative homeodomain transcription factor 1 FLJ11220 1p13.1 hypothetical protein FLJ11220 PTPN22 1p13.3-p13.1 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) LOC148280 1p13.1 hypothetical LOC148280 AP4B1 1p11.2 adaptor-related protein complex 4, beta 1 subunit DCLRE1B 1p11.2 DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae) HIPK1 1p12 DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae) HNOEL-iso 1p13.1 HNOEL-iso protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 3927 - 500 - -
    5 - 4390 - 500 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveesophagus   highly
     intestinelarge intestinecolon  
     mouth   highly
    Reproductivemale systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticerthrocyte
    Muscularmyocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve transmembrane spanning segments (12TM)
  • a cytoplasmic loop between TM6 and TM7
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Slc16a1 (87.6pc)
    homolog to rattus Slc16a1 (86.0pc)
    Homologene
    FAMILY
  • major facilitator superfamily
  • monocarboxylate porter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text basolateral
    basic FUNCTION
  • H+ coupled monocarboxylate transporter 1, mediating movement of lactate and pyruvate, branched-chain oxo acids, ketone bodies acetoacetate, beta-hydroxybutyrate and acetate across the colonocytes luminal membranes
  • involved in lactate enter in endothelial cells, and stimulatibg an autocrine NFKB/IL8 pathway driving cell migration and tube formation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism monocarbon , other
    signaling
    glucides
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • proton linked
  • protein
  • CD147, specifically
  • cell & other
    REGULATION
    repressed by miR-124
    Other upregulated in response to increased work
    ASSOCIATED DISORDERS
    corresponding disease(s) MCTD , HHF7
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    significantly increased in colorectal carcinomas. Gain of membrane expression directly related to the presence of vascular invasion
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbrain 
    may be a novel therapeutic target for treatment of malignant medulloblastomas
    ANIMAL & CELL MODELS