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FLASH GENE

Symbol

SLC16A1

contributors: mct - updated : 19-03-2017

HGNC name	solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
HGNC id	10922

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	HHF7 hyperinsulinemic hypoglycemia, familial, 7 MCTD monocarboxylic acid transporter deficiency
Location	1p13.2      Physical location : 113.454.471 - 113.498.975
Synonym name	monocarboxylate transporter 1
	solute carrier family 16 (monocarboxylic acid transporters), member 1
Synonym symbol(s)	MCT1, FLJ36745, MCT, MGC44475

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem
STRUCTURE	44.51 kb     5 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Binding site   transcription factor
text structure	PKC and AP2 binding sites in the promoter

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003051 5 - 3927 NP_003042 - 500 - - NM_001166496 5 - 4390 NP_001159968 - 500 - -

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly   intestine large intestine colon       mouth       highly Reproductive male system testis     highly Visual eye anterior segment cornea     Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     highly Connective adipose       Homo sapiens Muscular striatum cardiac     Muscular striatum skeletal

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic erthrocyte Muscular myocyte Visual epithelial cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	twelve transmembrane spanning segments (12TM)
	a cytoplasmic loop between TM6 and TM7

conjugated

PhosphoP

HOMOLOGY

interspecies	homolog to murine Slc16a1 (87.6pc)
	homolog to rattus Slc16a1 (86.0pc)

Homologene

FAMILY	major facilitator superfamily
	monocarboxylate porter family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	plasma membrane
text	basolateral

basic FUNCTION	H+ coupled monocarboxylate transporter 1, mediating movement of lactate and pyruvate, branched-chain oxo acids, ketone bodies acetoacetate, beta-hydroxybutyrate and acetate across the colonocytes luminal membranes
	hypoxia stimulates lactate release and modulates monocarboxylate transporter (SLC16A1, SLC16A2, and SLC16A4) expression in human adipocytes
	involved in lactate enter in endothelial cells, and stimulatibg an autocrine NFKB/IL8 pathway driving cell migration and tube formation
	lactate homeostasis participates in the regulation of the Schwann cells (SCs) myelination program and reveal that similar to CNS, PNS axon-glial metabolic interactions are most likely mediated by SLC16A4, SLC16A1
	modulates cancer cell pyruvate export and growth of tumors
	exhibits high-affinity l-lactate transport and broad substrate recognition
	mediate L-lactate transport, but, also transports L-5-oxoproline (L-OPro), and amino acid residues, M69 and F367, are key molecular elements for the transport of L-OPro

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

monocarbon , other

signaling

glucides

a component

INTERACTION

DNA

RNA

small molecule
	proton linked

protein

BSG is required for the expression of SLC16A1 and SLC16A4 in the corneal endothelium

cell & other

REGULATION

repressed by

miR-124

Other	upregulated in response to increased work
	SLC16A4, SLC16A1 are regulated via expression of their chaperone, BSG

ASSOCIATED DISORDERS

corresponding disease(s)

MCTD , HHF7

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   significantly increased in colorectal carcinomas. Gain of membrane expression directly related to the presence of vascular invasion tumoral     --over   in neoplastic lymphocytes 2) tumoral     --over   in glycolytic breast tumors, and high SLC16A1 expression predicts poor prognosis in breast cancer patients

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer brain   may be a novel therapeutic target for treatment of malignant medulloblastomas cancer     pharmacological inhibition of SLC16A1 and SLC16A4 combined with metformin treatment is a potential cancer therapy cancer brain glioma/neuroblstoma development of therapeutic approaches targeting SLC16A1 may be a promising strategy in glioblastoma treatment

ANIMAL & CELL MODELS