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FLASH GENE
Symbol SLC16A1 contributors: mct - updated : 19-03-2017
HGNC name solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
HGNC id 10922
Corresponding disease
HHF7 hyperinsulinemic hypoglycemia, familial, 7
MCTD monocarboxylic acid transporter deficiency
Location 1p13.2      Physical location : 113.454.471 - 113.498.975
Synonym name
  • monocarboxylate transporter 1
  • solute carrier family 16 (monocarboxylic acid transporters), member 1
  • Synonym symbol(s) MCT1, FLJ36745, MCT, MGC44475
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    STRUCTURE 44.51 kb     5 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site   transcription factor
    text structure PKC and AP2 binding sites in the promoter
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 3927 - 500 - -
    5 - 4390 - 500 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     intestinelarge intestinecolon  
     mouth   highly
    Reproductivemale systemtestis  highly
    Visualeyeanterior segmentcornea   Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Connectiveadipose    Homo sapiens
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticerthrocyte
    Muscularmyocyte
    Visualepithelial cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • twelve transmembrane spanning segments (12TM)
  • a cytoplasmic loop between TM6 and TM7
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Slc16a1 (87.6pc)
    homolog to rattus Slc16a1 (86.0pc)
    Homologene
    FAMILY
  • major facilitator superfamily
  • monocarboxylate porter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text basolateral
    basic FUNCTION
  • H+ coupled monocarboxylate transporter 1, mediating movement of lactate and pyruvate, branched-chain oxo acids, ketone bodies acetoacetate, beta-hydroxybutyrate and acetate across the colonocytes luminal membranes
  • hypoxia stimulates lactate release and modulates monocarboxylate transporter (SLC16A1, SLC16A2, and SLC16A4) expression in human adipocytes
  • involved in lactate enter in endothelial cells, and stimulatibg an autocrine NFKB/IL8 pathway driving cell migration and tube formation
  • lactate homeostasis participates in the regulation of the Schwann cells (SCs) myelination program and reveal that similar to CNS, PNS axon-glial metabolic interactions are most likely mediated by SLC16A4, SLC16A1
  • modulates cancer cell pyruvate export and growth of tumors
  • exhibits high-affinity l-lactate transport and broad substrate recognition
  • mediate L-lactate transport, but, also transports L-5-oxoproline (L-OPro), and amino acid residues, M69 and F367, are key molecular elements for the transport of L-OPro
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism monocarbon , other
    signaling
    glucides
    a component
    INTERACTION
    DNA
    RNA
    small molecule
  • proton linked
  • protein
  • BSG is required for the expression of SLC16A1 and SLC16A4 in the corneal endothelium
  • cell & other
    REGULATION
    repressed by miR-124
    Other upregulated in response to increased work
    SLC16A4, SLC16A1 are regulated via expression of their chaperone, BSG
    ASSOCIATED DISORDERS
    corresponding disease(s) MCTD , HHF7
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    significantly increased in colorectal carcinomas. Gain of membrane expression directly related to the presence of vascular invasion
    tumoral     --over  
    in neoplastic lymphocytes 2)
    tumoral     --over  
    in glycolytic breast tumors, and high SLC16A1 expression predicts poor prognosis in breast cancer patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbrain 
    may be a novel therapeutic target for treatment of malignant medulloblastomas
    cancer  
    pharmacological inhibition of SLC16A1 and SLC16A4 combined with metformin treatment is a potential cancer therapy
    cancerbrainglioma/neuroblstoma
    development of therapeutic approaches targeting SLC16A1 may be a promising strategy in glioblastoma treatment
    ANIMAL & CELL MODELS