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FLASH GENE
Symbol SLC15A4 contributors: mct/ - updated : 31-03-2015
HGNC name solute carrier family 15, member 4
HGNC id 23090
Location 12q24.32      Physical location : 129.277.738 - 129.308.541
Synonym name peptide-histidine transporter 4
Synonym symbol(s) PHT1, PTR4, FP12591
DNA
TYPE functioning gene
STRUCTURE 30.80 kb     8 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 2789 62 577 - 2008 18259684
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine   highly Homo sapiens
Endocrinethyroid   highly
Lymphoid/Immunelymph node   highly
 spleen   highly
Nervousbraindiencephalonhypothalamus  
Visualeyeretina   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal highly
cells
SystemCellPubmedSpeciesStageRna symbol
Lymhoid/Immunelymphocyte
Lymphoid/Immunedendritic cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a dileucine motif in its N-terminal cytoplasmic domain (AP3B1 associates with acidic dileucine-based motifs to shuttle target proteins from the trans-Golgi to lysosomes)
  • HOMOLOGY
    Homologene
    FAMILY
  • proton-dependent oligopeptide transporters (PRT2/POT) family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • involved in proton-dependent uptake of di- or tri-peptides, and to a minor extent tetra-peptides
  • may participate in the intestinal absorption of peptide-based agents
  • could participate to recycling of peptides derived from extracellular and lysosomal thyroglobulin proteolysis, both essential steps for thyroid hormone synthesis
  • with AP3B1, and Hermansky-Pudlak syndrome proteins, are required for Toll-like receptor signaling in plasmacytoid dendritic cells
  • obscure solute channel protein, essential for TLR-mediated signaling in plasmacytoid dendritic cells
  • may also have a role in maintaining the appropriate pH of the endosomal compartment as endosomal acidification is required for optimal TLR7 and TLR9 activation
  • required for Plasmacytoid dendritic cells (pDCs) sensing of TLR ligands, is required to control persistent viral infection
  • lysosome-resident, proton-coupled amino-acid transporter that moves histidine and oligopeptides from inside the lysosome to the cytosol of eukaryotic cells
  • SLC15A4 transporter activity was necessary for the TLR-triggered cytokine production
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with AP3B1
  • SLC15A4 function is required for intact class switch recombination to IgG2c in response to TLR9 stimulation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    -
    Susceptibility to type 2 diabetes
    Variant & Polymorphism SNP increasing the risk of type 2 diabetes
    Candidate gene candidate susceptibility locus for systemic lupus erythematosus (SLE)
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyautoimmuneLupus
    attractive target for pharmacotherapy aimed at preventing aberrant type I IFN production as occurs in diseases such as SLE
    immunologyautoimmuneLupus
    SLC15A4 may provide important targets for therapeutic intervention in human lupus
    ANIMAL & CELL MODELS