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FLASH GENE

Symbol

SLC13A5

contributors: mct - updated : 28-02-2014

HGNC name	solute carrier family 13 (sodium-dependent citrate transporter), member 5
HGNC id	23089

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	EIEE25 early-onset epileptic encephalopathy-25
Location	17p13.1      Physical location : 6.588.040 - 6.616.740
Synonym name	sodium-coupled citrate transporter
	solute carrier family 13 member 5
Synonym symbol(s)	NACT, MGC138356, mindy

DNA

TYPE	functioning gene
STRUCTURE	28.71 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site
text structure	CREB-binding site within thepromoter

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001284510 11 - 3187 NP_001271439 - 525 - 2002 12177002 NM_001284509 12 - - NP_001271438 - - - 2002 12177002 NM_001143838 11 - 3178 NP_001137310 - 522 - 2002 12177002 NM_177550 12 - 3316 NP_808218 - 568 - 2002 12177002

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver         Homo sapiens Nervous brain forebrain cerebral cortex     Mus musculus   brain         Homo sapiens Reproductive male system testis

cells

System Cell Pubmed Species Stage Rna symbol Digestive hepatocyte Homo sapiens Nervous neuron Mus musculus

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	liver, eye

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

11 transmembrane domains

conjugated

GlycoP

mono polymer

homomer , dimer

HOMOLOGY

intraspecies

homolog to SLC13A2,SLC13A3

Homologene

FAMILY	SLC13A transporter family
	NADC subfamily

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	playing an important role in the cellular utilization of citrate in blood for the synthesis of fatty acids and cholesterol (liver) and for the generation of energy (liver and brain)
	may be facilitating the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol
	tricarboxylate plasma transporter with a preference for citrate
	primarily a citrate transporter located in the liver and brain, and its activity may regulate metabolic processes
	CREB-dependent glucagon target gene that is induced in fasting and in type 2 diabetes

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

energetic

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

EIEE25

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed diabete type 2   might be a therapeutic target for the treatment of obesity and type 2 diabetes obesity     might be a therapeutic target for the treatment of obesity and type 2 diabetes

ANIMAL & CELL MODELS

	Nact (also known as Slc13a5)-knockout mice have been found to have increased hepatic mitochondrial biogenesis, higher lipid oxidation and energy expenditure, and reduced lipogenesis, which taken together protect the mice from obesity and insulin resistance
	mIndy was induced in livers of fasted as well as in high-fat-diet-streptozotocin diabetic rats, in which Creb is constitutively activated. mIndy induction was completely prevented when Creb was depleted in these rats by antisense oligonucleotides