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FLASH GENE
Symbol SLC13A4 contributors: mct - updated : 28-02-2014
HGNC name solute carrier family 13 (sodium/sulfate symporters), member 4
HGNC id 15827
Location 7q33      Physical location : 135.365.992 - 135.412.933
Synonym name sulphate transporter 1
Synonym symbol(s) SUT-1, SUT1, hNaS2
DNA
TYPE functioning gene
STRUCTURE 46.00 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter (CAAT box)
cytosine-phosphate-guanine/HTF
Binding site   transcription factor
text structure 5'-flanking region contains CAAT- and GC-box motifs, and a number of putative transcription factor binding sites, including GATA-1, AP-1, and AP-2 consensus sequences
MAPPING cloned Y linked N status provisional
Physical map
FLJ32786 7q33 hypothetical protein FLJ32786 SLC35B4 7q33 solute carrier family 35, member B4 AKR1B1 7q25 aldo-keto reductase family 1, member B1 (aldose reductase) AKR1B10 7q33 aldo-keto reductase family 1, member B10 (aldose reductase) LOC392097 7 similar to aldo-keto reductase family 1, member B10; aldose reductase-like 1; aldo-keto reductase family 1, member B11 (aldose reductase-like); aldose reductase-like peptide; aldose reductase-related protein; small intestine reducta BPGM 7q32 2,3-bisphosphoglycerate mutase LOC392098 7 similar to beta-tubulin CALD1 7q33-q34 caldesmon 1 LOC340351 7q33 hypothetical protein LOC340351 LOC346671 7q33 pseudogene of RING finger protein 14 FLJ11000 7q33 hypothetical protein FLJ11000 MGC5242 7q33 hypothetical protein MGC5242 KIAA1466 7q33 KIAA1466 protein HSPC049 7q33 HSPC049 protein LOC346673 7q33 STRA8 LOC346674 7q33 similar to Na+/L-ascorbic acid transporter 1; SVCT1 CNOT4 7q33 CCR4-NOT transcription complex, subunit 4 LOC392099 7 hypothetical gene supported by AK075360; NM_003002 NUP205 7q33 nucleoporin 205kDa LOC136321 7q33 similar to 60S ribosomal protein L15 SLC13A4 7q33 solute carrier family 13 (sodium/sulfate symporters), member 4 LOC389558 7 similar to HWKM1940 MTPN 7q33-q35 myotrophin LOC392100 7 similar to protease (prosome, macropain) 26S subunit, ATPase 1 LOC389559 7 LOC389559 CHRM2 7q31-q35 cholinergic receptor, muscarinic 2 LOC389560 7 LOC389560 PTN 7q33-q34 pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1) DGKI 7q32.3-q33 diacylglycerol kinase, iota
regionally located between markers D7S500 and D7S509
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivefemale systemplacenta    Homo sapiens
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text
  • most abundant sulfate transporter mRNAs, which localized to syncytiotrophoblast cells
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to rattus Nasi-1
    Homologene
    FAMILY solute carrier family 13 (sodium/sulfate symporters)
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • sodium/sulfate cotransporter mediating sulfate reabsorption in the high endothelial venules
  • physiological roles for SLC13A4 and SLC26A2 in human placental sulfate transport
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS