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FLASH GENE
Symbol SLC13A2 contributors: mct - updated : 28-02-2014
HGNC name solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
HGNC id 10917
Location 17p13.2      Physical location : 26.800.663 - 26.824.796
Synonym symbol(s) NADC1, NaDC-1, CTR2
DNA
TYPE functioning gene
STRUCTURE 23.00 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map pter - D17S2123 - [cen] - D17S841 - qter
Authors Mann (99)
Text [SLC13A2 ]
Physical map
LOC390782 17 similar to 60S ribosomal protein L10 (QM protein) (Tumor suppressor QM) (Laminin receptor homolog) NLK 17q11.2 nemo-like kinase PYY2 17q11.1-q11.2 peptide YY, 2 (seminalplasmin) PPY2 17q11.1-q11.2 pancreatic polypeptide 2 LOC339274 17q11.2 similar to Hypothetical protein KIAA0563 FLJ40504 17q11.2 hypothetical protein FLJ40504 MAC30 17q11.2 hypothetical protein FLJ40504 LOC90410 17q11.2 intraflagellar transport protein IFT20 TNFAIP1 17q11 tumor necrosis factor, alpha-induced protein 1 (endothelial) PDIP38 MGC45714 17q11.2 hypothetical protein MGC45714 VTN 17q11.2 vitronectin (serum spreading factor, somatomedin B, complement S-protein) SARM1 17q11 sterile alpha and TIR motif containing 1 MGC9564 17q11.2 similar to RIKEN cDNA 1110002C08 gene LOC388363 17 similar to 40S ribosomal protein S7 (S8) SLC13A2 17p11.1-q11.1 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 FOXN1 17q11.2 forkhead box N1 UNC119 17q11.2 unc-119 homolog (C. elegans) PIGS 17p13.2 phosphatidylinositol glycan, class S ALDOC 17q11.2 aldolase C, fructose-bisphosphate SPAG5 17q11.1 sperm associated antigen 5 FLJ25006 17q11.2 hypothetical protein FLJ25006 KIAA0100 17q11.2 KIAA0100 gene product SDF2 17q11.2 stromal cell-derived factor 2 SUPT6H 17q11.2 suppressor of Ty 6 homolog (S. cerevisiae) MGC39650 17q11.2 hypothetical protein MGC39650 RAB34 17q11.1 RAB34, member RAS oncogene family RPL23A 17q11 ribosomal protein L23a LOC116238 17q11.2 hypothetical protein BC014072 NEK8 17q11.1 NIMA (never in mitosis gene a)- related kinase 8 TRAF4 17q11-q12 TNF receptor-associated factor 4 FLJ10700 17q11.2 hypothetical protein FLJ10700 ERAL1 17q11.2 Era G-protein-like 1 (E. coli) FLOT2 17q11.2-q12 flotillin 2 MGC23280 17q11.2 hypothetical protein MGC23280 PHF12 17q11.2 PHD finger protein 12
regionally located between markers D17S2123 and D17S841
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 1952 - 592 - Okamoto (2007)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine    Homo sapiens
Respiratoryrespiratory tracttrachea   
Urinarykidneytubuleconvoluted tubuleproximal tubule  Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Urinarytubular cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • at least eight transmembrane domains
  • two potential protein kinase C phosphorylation sites, and two N-glycosylation sites
  • conjugated GlycoP , PhosphoP
    HOMOLOGY
    interspecies homolog to murine Slc13a2
    homolog to C.elegans f31f6.6
    Homologene
    FAMILY
  • NADC/P/Ph087 family of transporters
  • NADC subfamily
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • involved in osmoregulation
  • reabsorbs Krebs cycle intermediates, such as succinate and citrate, from the glomerular filtrate
  • involved in cotransport of sodium ions and dicarboxylates such as succinate and citrate
  • SLC13A2 , SLC13A5 and SLC13A3, transport di- and tri-carboxylate Krebs cycle intermediates such as succinate, citrate and alpha-ketoglutarate
  • primarily found on the apical membranes of renal proximal tubule and small intestinal cells, is involved in regulating urinary levels of citrate and plays a role in kidney stone development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS excretion , active transport
    text small molecule transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    sodium Na+ (low affinity)
    protein
    cell & other
    REGULATION
    Other acidic pH for citrate transport
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS