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FLASH GENE
Symbol SLC12A9 contributors: mct/npt - updated : 06-10-2009
HGNC name solute carrier family 12 (potassium/chloride transporters), member 9
HGNC id 17435
Location 7q22.1      Physical location : 100.450.357 - 100.464.633
Synonym name
  • cation-chloride cotransporter-interacting protein 1
  • CCC-interacting protein 1
  • potassium-chloride transporter 9
  • Synonym symbol(s) CIP1, WO3.3, CCC6, FLJ46905
    DNA
    TYPE functioning gene
    STRUCTURE 14.28 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    PILRA 7q22 paired immunoglobin-like type 2 receptor alpha ZCWPW1 7q22.1 zinc finger, CW-type with PWWP domain 1 FLJ20257 7q22.1 hypothetical protein FLJ20257 MGC22793 7q22.1 hypothetical protein MGC22793 THG-1 7p21-p15 TSC-22-like FLJ37538 7q22.1 hypothetical protein FLJ37538 HRBL 7q22 HIV-1 Rev binding protein-like LOC392081 7 similar to insulin receptor substrate like protein LRRN4 7q22 leucine rich repeat neuronal 4 FBXO24 7q22 F-box only protein 24 PCOLCE 7q22 procollagen C-endopeptidase enhancer AF053356_CDS3 7q22 hypothetical protein AF053356_CDS3 TFR2 7q22 transferrin receptor 2 ACTL6 7q22 actin-like 6 GNB2 7q21.1-q22.2 guanine nucleotide binding protein (G protein), beta polypeptide 2 PERQ1 7q22 PERQ amino acid rich, with GYF domain 1 RPP20 7q22 POP7 (processing of precursor, S. cerevisiae) homolog EPO 7q21.3-q22.1 erythropoietin ZAN 7q22 zonadhesin EPHB4 7q32-q36 EphB4 LOC285995 7q22.1 hypothetical LOC285995 SLC12A9 7q22 solute carrier family 12 (potassium/chloride transporters), member 9 TRIP6 7q22 thyroid hormone receptor interactor 6 ARS2 7q21 arsenate resistance protein ARS2 ACHE 7q22.1 acetylcholinesterase (YT blood group) MUC3B 7q22 mucin 3B LOC219612 7q22.1 hypothetical gene supported by AK025404 MUC17 7q22 mucin 17 TRIM56 7q11.2 tripartite motif-containing 56 SERPINE1 7q21.3-q22.1 serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 AP1S1 7q11.22 adaptor-related protein complex 1, sigma 1 subunit VGF 7q22 VGF nerve growth factor inducible FLJ39237 7q22.1 FLJ39237 protein MGAT3 22q13.1 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase PLOD3 7q36 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 ZNHIT1 7q22.1 zinc finger, HIT domain containing 1 CLDN15 7q22 claudin 15 TTC11 7q22.1 tetratricopeptide repeat domain 11
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 3308 - 914 - Caron (2000)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 12-transmembrane domain (TM) region,
  • two N-linked glycosylation sites between TM(5) and TM(6), and
  • a large intracellular loop at the C-terminus containing protein kinase C phosphorylation sites (Wenz 2009)
  • HOMOLOGY
    interspecies homolog to C .elegans k02a2.3.
    Homologene
    FAMILY
  • SLC12A transporter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may be modulating cation-chloride cotransporter (CCC)activity or kinetics through heterodimer formation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • potent activator of SLC12A5 (activates SLC12A5 by heteromer formation)(Wenz 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS