basic FUNCTION
| regulating transcellular movement of chloride in colon |
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maybe involved in endolymph secretion and in regulating cell volume |
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facilitating seizures in the developing hippocampus |
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plays a key role in epithelial salt secretion and cell volume regulation |
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major pathway for Cl- accumulation in glioma cells, and genetic or pharmacologic inhibition of SLC12A2 is associated with a marked reduction in glioma cell invasion |
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regulates intracellular Cl- concentration in many cell types and is a critical part of the Cl- secretory pathway in salt secreting epithelia |
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in the brain is critically involved in maintaining chloride homeostasis and in neuronal responses mediated by GABA(A) receptors |
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SLC12A2 co-transporter is involved in the maintenance of a high intracellular chloride concentration [Cl(-)] in beta-cells and its inhibition with BTD blocks glucose-induced insulin secretion |
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play important roles in Na(+) and K(+) concentrations in key physiological systems, including cardiac, vascular, renal, nervous, and sensory systems |
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couples the movement of Na(+), K(+), and Cl(-) ions across the plasma membrane of most cells and thus plays a central role in cellular homeostasis |
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involved in cell volume/ion regulation |
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involved in insulin secretion and a single SLC12A2 allele may protect beta-cells from failure due to increased homeostatic expression of SLC12A1 |