basic FUNCTION
| regulator of mycobacterial infection (activator of macrophage) |
|
proton-divalent cation transporter having an important role in regulating macrophage functions that affect innate resistance as well as immune responses |
|
regulate ion homeostasis from endosomal compartments and having pleiotropic effects on pro-inflammatory responses |
|
involved in defense against intracellular pathogens |
|
plays important roles in macrophage activation and displays pleiotropic effects on various macrophage functions, including the regulation of tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta) (n plays important roles in macrophage activation and displays pleiotropic effects on various macrophage functions, including the regulation of tumor necrosis factor-alpha |
|
contributes to phagocyte-autonomous antimicrobial defense mechanisms |
|
promotes potentially efficient hemoglobin iron recycling in macrophages, suggesting that mutations in SLC11A1 could result in a novel form of human hereditary iron overload |
|
SLC11A1, SLC11A2, are iron transporters that localize, respectively, to the early and late endosomal compartments |
|
have roles in phagosome maturation and cell activation |