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FLASH GENE
Symbol SLC10A6 contributors: SGE/npt - updated : 09-10-2018
HGNC name solute carrier family 10 (sodium/bile acid cotransporter family), member 6
HGNC id 30603
Location 4q21.3      Physical location : 87.744.620 - 87.770.416
Synonym name sodium-dependent organic anion transporter
Synonym symbol(s) MGC129575, MGC129576, SOAT
DNA
TYPE functioning gene
STRUCTURE 25.80 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1502 - 377 - 2007 17491011
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestiveliver   lowly Homo sapiens
Endocrinepancreas   highly
Nervousbrain   lowly
Reproductivefemale systemovary  lowly
 female systemplacenta  highly
 female systembreastmammary gland moderately
 male systemtestis  predominantly Homo sapiens
Respiratorylung   moderately
Urinarykidney   lowly
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivegerm cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • nine transmembrane domains
  • an N-terminus outside the cell
  • an intracellular C-terminus
  • conjugated GlycoP , PhosphoP
    HOMOLOGY
    intraspecies paralog to SLC10A2
    Homologene
    FAMILY
  • sodium:bile acid symporter family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • SLC10A6 completely co-localized with SLC10A1 at the plasma membrane
  • basic FUNCTION
  • specifically transports steroid sulfates such as oestrone-3-sulfate and dehydroepiandrosterone sulfate in a sodium-dependent manner, and is considered to play an important role for the cellular delivery of these prohormones in testes, placenta, adrenal gland and probably other peripheral tissues
  • could also contribute to placenta progesterone synthesis
  • specifically transports steroid sulfates such as oestrone-3-sulfate and dehydroepiandrosterone sulfate in a sodium-dependent manner, and is considered to play an important role for the cellular delivery of these prohormones in testes, placenta, adrenal gland and probably other peripheral tissues
  • having physiological meaning for hormone response of testis and placenta on sulfoconjugated steroid hormones and also for their toxicologic exposure to sulfoconjugated pyrene carcinogens as well as for placental transport of sulfoconjugated bile acids
  • transport steroid sulfates
  • SLC10A6 function contributes likely to the hepatic inflammatory response
  • having highly specific transport activity for sulfated steroids
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • Na+ dependent
  • protein
  • SLC10A1 co-localizes and associates with SLC10A4 and SLC10A6
  • cell & other
    REGULATION
    inhibited by dihydroxylated or sulfated bile acids
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • male Slc10a6-/- knockout mice showed significantly higher serum levels for cholesterol sulfate compared to their wildtype controls, but Slc10a6 -/- knockout mice were fertile, produced normal litter sizes, and had normal spermatogenesis and sperm vitality