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FLASH GENE
Symbol SLC10A1 contributors: mct - updated : 09-10-2018
HGNC name solute carrier family 10 (sodium/bile acid cotransporter family), member 1
HGNC id 10905
Location 14q24.1      Physical location : 70.242.551 - 70.264.006
Synonym name Na(+)/taurocholate cotransporter protein
Synonym symbol(s) NTCP, NTCP1
DNA
TYPE functioning gene
STRUCTURE 21.46 kb     5 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Binding site   transcription factor
text structure a number of putative DNA-binding sites for the liver-enriched binding factors HNF3,HNF6 and CEBP as well as binding sites for numerous ubiquitous transcription factors and potential sites for STAT proteins
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1631 - 349 - 2018 29024779
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver     Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Digestivehepatocyte Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • extracellular N-terminus containing two N-linked glycosylation sites
  • an intracellular directed C-terminus flanking seven or nine transmembrane alpha-helices
  • a dileucine motif located in the third intracellular loop of SLC10A1 was essential for endocytosis but also for processing and plasma membrane targeting, suggesting a dual function of this motif for intracellular trafficking of SLC10A1
    • conjugated GlycoP
    mono polymer dimer
    HOMOLOGY
    interspecies ortholog to murine Slc10a1
    homolog to rattus Slc10a1
    homolog to C.elegans R09F10.6
    Homologene
    FAMILY
  • solute carrier family 10, member 1, sodium/taurocholate cotransport
  • sodium-bile acid symporter family (SBF)
    • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • liver sinusoidal membranes
  • basolateral membrane of hepatocytes
  • SLC10A6 completely co-localized with SLC10A1 at the plasma membrane
    • basic FUNCTION
  • participating in the enterohepatic circulation of bile acids
  • in hepatocytes, the sodium taurocholate cotransporting polypeptide (SLC10A1) is a major determinant of intracellular bile salt levels
  • adopts a dimeric structure in which individual subunits are functional
  • SLC10A1 and SLC10A2 are the best characterized family members, playing pivotal roles in hepatic and intestinal bile acid uptake respectively
  • mediates taurocholate (TC) uptake across the sinusoidal membrane of hepatocytes
  • is the major uptake transporter for bile salts into liver parenchymal cells, and PRKC-mediated endocytosis was shown to regulate the number of SLC10A1 molecules at the plasma membrane
  • has been identified as a receptor for the hepatitis B and D virus
  • is believed to be pivotal for hepatic uptake of conjugated bile acids
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text bile acid : sodium symporter
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • inhibition of taurocholate (TC) uptake by Nitric oxide involves S-nitrosylation of SLC10A1
  • co-localizes and associates with SLC10A4 and SLC10A6
  • interaction of SLC22A7 and sodium taurocholate cotransporting polypeptide (SLC10A1) with antineoplastic drugs
  • reported as a functional receptor for hepatitis B virus (HBV) infection
    • cell & other
    REGULATION
    Other transcriptional by C/EBP
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in PFIC (progressive familial intrahepatic cholestasis)
    constitutional     --over  
    of NR1H4, NR0B2, SLC10A1 and ABCB11 was significantly up-regulated in the non-alcoholic steatohepatitis (NASH) in comparison with simple steatosis (SS) patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS