basic FUNCTION
| involved in replication-dependent histone gene expression |
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cell cycle-regulated factor required for histone pre-mRNA processing (Zheng 2003) |
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regulated during the cell cycle, accumulating as cells enter S phase and being rapidly degraded as cells exit S phase (Zheng 2003) |
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regulates translation of histone mRNA during mammalian oogenesis (Allard 2005) |
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binds to the stem-loop and the U7 snRNP, which anchors to histone pre-mRNAs by annealing to the histone downstream element (HDE) (Jaeger 2006) |
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function as the molecular ruler to determine the site of 3 prime-end processing in mammalian histone pre-mRNA (Yang 2009) |
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is required for optimal histone biogenesis, a highly regulated process that is intimately coordinated with DNA synthesis and DNA replication fork progression |
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having a role in histone mRNA export (Sullivan 2009) |
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plays a pivotal function in mediating histone biogenesis via a direct role in histone synthesis but also in the targeted degradation of histone mRNA at the end of S phase |
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is required for retinal stem cell maintenance |
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SLBP and NOTCH1 signaling are required for retinal progenitor cell proliferation and subsequent neurogenesis |
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important roles of SLBP in retinal development |