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FLASH GENE
Symbol SLBP contributors: mct/npt - updated : 21-12-2016
HGNC name stem-loop binding protein
HGNC id 10904
Location 4p16.3      Physical location : 1.694.526 - 1.714.030
Synonym name
  • histone binding protein 1
  • stem-loop (histone) binding protein
  • hairpin binding protein, histone
  • Synonym symbol(s) HBP1, HBP
    DNA
    TYPE functioning gene
    STRUCTURE 19.90 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1743 - 270 - 1997 9049306
    - - 2141 - 235 - 1997 9049306
    - - 2129 - 231 - 1997 9049306
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid    
    Lymphoid/Immunelymph node   highly
    Nervousbrainhindbraincerebellum  
    Reproductivefemale systemplacenta  highly
    Urinarybladder    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, pregnancy
    Text stem cells, placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer monomer
    HOMOLOGY
    Homologene
    FAMILY
  • SLBP family
  • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus,nucleoplasm
    text on the polyribosomes
    basic FUNCTION
  • involved in replication-dependent histone gene expression
  • cell cycle-regulated factor required for histone pre-mRNA processing (Zheng 2003)
  • regulated during the cell cycle, accumulating as cells enter S phase and being rapidly degraded as cells exit S phase (Zheng 2003)
  • regulates translation of histone mRNA during mammalian oogenesis (Allard 2005)
  • binds to the stem-loop and the U7 snRNP, which anchors to histone pre-mRNAs by annealing to the histone downstream element (HDE) (Jaeger 2006)
  • function as the molecular ruler to determine the site of 3 prime-end processing in mammalian histone pre-mRNA (Yang 2009)
  • is required for optimal histone biogenesis, a highly regulated process that is intimately coordinated with DNA synthesis and DNA replication fork progression
  • having a role in histone mRNA export (Sullivan 2009)
  • plays a pivotal function in mediating histone biogenesis via a direct role in histone synthesis but also in the targeted degradation of histone mRNA at the end of S phase
  • is required for retinal stem cell maintenance
  • SLBP and NOTCH1 signaling are required for retinal progenitor cell proliferation and subsequent neurogenesis
  • important roles of SLBP in retinal development
  • CELLULAR PROCESS nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
  • histone hairpin binding
  • stem-loop binding
  • interacting with LSM10, LSM11 and ZNF473 (with LSM10 and LSM11, which are part of the core U7 Sm complex, and ZNF473, helps stabilize binding of the U7 snRNP to the histone pre-mRNA)(Wagner 2006)
  • interacting with MIF4GD (required for activation of histone mRNA translation by the stem-loop binding protein, SLBP)(Cakmakci 2008)
  • a function of NELFA (WHSC2) is the recruitment of SLBP to the 3prime ends of histone pre-mRNAs
  • binds to a stem-loop structure at the 3'-end of histone mRNAs, and regulates a replication-dependent synthesis and degradation of histone proteins
  • SLBP is a novel substrate of FBXO30 (overexpression caused by FBXO30 depletion results in a remarkable overload of histone H3 on chromosomes that excessively condenses chromosomes and inhibits chromosome segregation)
  • cell & other
    REGULATION
    repressed by CCNA1/CDC2 (increase in CCNA1/CDC2 activity at the end of S phase triggers degradation of SLBP at S/G(2)(Koseoglu 2008)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    of SLBP and/or NELFA (WHSC2) protein in WHS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS