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FLASH GENE
Symbol SLAMF8 contributors: mct - updated : 16-02-2016
HGNC name SLAM family member 8
HGNC id 21391
Location 1q23.2      Physical location : 159.796.478 - 159.807.281
Synonym name
  • BCM-like membrane protein precursor
  • B lymphocyte activator macrophage expressed
  • Synonym symbol(s) SBBI42, BLAME, CD353
    DNA
    TYPE functioning gene
    STRUCTURE 10.85 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    Physical map
    NECL1 1q21.2-22 vang-like 2 (van gogh, Drosophila) FY 1q21-q22 Duffy blood group LOC127150 1q23.1 similar to mucosal pentraxin LOC391117 1 similar to olfactory receptor MOR267-8 FCER1A 1q23 Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide LOC391118 1 similar to olfactory receptor MOR267-3 LOC391119 1 similar to olfactory receptor GA_x6K02T2R7CC-664297-665229 LOC343409 1q23.1 similar to Olfactory receptor 10J1 (Olfactory receptor-like protein HGMP07J) LOC391120 1 similar to olfactory receptor MOR267-3 LOC391121 1 similar to olfactory receptor MOR267-3 OR10J1 1q22 olfactory receptor, family 10, subfamily J, member 1 LOC127385 1q23.1 similar to Olfactory receptor 10J5 LOC391122 1 similar to porcine serum amyloid P component (SAP) APCS 1q23.2 amyloid P component, serum LOC339511 1q23.1 similar to Olfactory receptor 10J6 LOC171422 1q23.1 C-reactive protein pseudogene CRP 1q23.2 C-reactive protein, pentraxin-related FLJ20442 1q23.1 hypothetical protein FLJ20442 LOC343413 1q23.1 similar to Fc receptor homolog expressed in B cells; Fc receptor related protein X SLAMF8 1q23.1 SLAM family member 8 LOC391123 1 similar to hypothetical protein A030011M19 NESG1 1q22 similar to hypothetical protein A030011M19 TAGLN2 1q22 transgelin 2 IGSF9 1q22-q23 immunoglobulin superfamily, member 9 SLAMF9 1q23.1 SLAM family member 9 LOC391124 1 similar to ribosomal protein L27a; ribosomal protein L29 homolog (yeast) PIGM 1q22 phosphatidylinositol glycan, class M KCNJ10 1q22 potassium inwardly-rectifying channel, subfamily J, member 10 KCNJ9 1q22 potassium inwardly-rectifying channel, subfamily J, member 9 IGSF8 1q23.1 immunoglobulin superfamily, member 8 ATP1A2 1q22 ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide ATP1A4 1q22 ATPase, Na+/K+ transporting, alpha 4 polypeptide CASQ1 1q22 calsequestrin 1 (fast-twitch, skeletal muscle) PEA15 1q22 phosphoprotein enriched in astrocytes 15 H326 1q22-q23 H326 LOC388707 1 hypothetical gene supported by BC005391; NM_002295 COPA 1q22 coatomer protein complex, subunit alpha PXF 1q22 peroxisomal farnesylated protein NCSTN 1q22 peroxisomal farnesylated protein NHLH1 1q22 nescient helix loop helix 1 VANGL2 1q22 vang-like 2 (van gogh, Drosophila) SLAMF6 1q23.1 SLAM family member 6
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 3316
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Lymphoid/Immunelymph node   highly
     thymus    
    Reproductivefemale systembreastmammary gland  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Lymphoid/Immunedendritic cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one immunoglobulin-like c2-type domain
  • one immunoglobulin-like v-type domain
  • HOMOLOGY
    Homologene
    FAMILY CD2 family of cell surface proteins
    CATEGORY receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text attached to the membrane by a GPI-anchor
    basic FUNCTION
  • playing a role in B lineage commitment and/or modulation of signal through the B cell receptor
  • functions as a coreceptor for lymphocyte activation and/or adhesion via extravellular and cytoplasmic domains
  • in response to inflammation-associated stimuli, the inducible receptor Slamf8 negatively regulates inflammatory responses
  • natural killer T (NKT) cells and innate CD8(+) T cell development can be regulated in a SAP-dependent and -independent fashion by SLAMF receptors, in which SLAMF1, SLAMF6, and SLAMF8 affect development of NKT cells, and CD84, SLAMF7, and SLAMF8 affect the development of innate CD8(+) T cells
  • is a negative regulator of ROS in response to Gram+ and Gram- bacteria
  • SLAMF1 and SLAMF8 govern ROS-dependent innate immune responses of myeloid cells, thus modulating migration of these cells during inflammation in an opposing manner
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by interferon gamma
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS