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FLASH GENE
Symbol SLAMF7 contributors: mct - updated : 16-02-2016
HGNC name SLAM family member 7
HGNC id 21394
Location 1q23.3      Physical location : 160.709.076 - 160.724.600
Synonym name
  • 19A24 protein
  • CD2-like receptor activating cytotoxic cells
  • novel LY9 (lymphocyte antigen 9) like protein
  • Synonym symbol(s) CRACC, 19A, CS1, CD319
    DNA
    TYPE functioning gene
    STRUCTURE 15.77 kb     5 Exon(s)
    regulatory sequence Promoter (CAAT box)
    Binding site
    text structure
  • promoter region contains a BLIMP1/PRDM1 binding site
  • proximal region of promoter contains a CAAT box and atypical TATA-box that might result in common transcription initiation at -29 nucleotides upstream of the ATG translation start codon
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2908 - 335 - 2004 15368295
  • CS1L
  • may differentially regulate human NK cell functions
  • activating receptor
  • 4 - 2411 - 165 - 2004 15368295
    6 - 2804 - 296 - 2004 15368295
  • CS1-S
  • lacks ITSM
  • may differentially regulate human NK cell functions
  • 5 - 2515 - 204 - 2004 15368295
    6 - 2625 - 241 - 2004 15368295
    6 - 2587 - 228 - 2004 15368295
    5 - 2483 - 189 - 2004 15368295
    5 - 2467 - 188 - 2004 15368295
    5 - 2363 - 149 - 2004 15368295
    6 - 2369 - 201 - 2004 15368295
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
     spleen   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticplasma    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    Lymphoid/Immuneactivated B lymphocyte
    Lymphoid/Immunedendritic cell
    Lymphoid/Immunenatural killer Homo sapiens
    Lymphoid/ImmuneT cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a hydrophobic signal peptide
  • two Ig superfamily domains containing seven putative N-glycosylation sites
  • a transmembrane domain
  • cytoplasmic domain of CS1 containing four immunoreceptor tyrosine-based switch motif (ITSM)
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • CD2 subset of immunoglobulin superfamily (IgSF), CD2 family expressed on natural killer (NK), T and stimulated B cells
  • SLAM (Signaling Lymphocyte Activation Molecule) family receptors
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • receptor present on immune cells, including natural killer (NK) cells
  • basic FUNCTION
  • receptor activity, mediating lysis by activating cytotoxic cells
  • triggers ERK phosphorylation and activation
  • functioning as a self-ligand and its homophilic interaction regulates NK cell cytolytic activity
  • SLAMF1, CD48, CD84, CD244, LY9, SLAMF6, SLAMF7 play an essential and non-redundant role in the control of humoral immune responses
  • is a self-ligand and has both activating and inhibitory functions in Natural Killer cells
  • plays an inhibitory role in human monocytes to control proinflammatory immune responses
  • natural killer T (NKT) cells and innate CD8(+) T cell development can be regulated in a SAP-dependent and -independent fashion by SLAMF receptors, in which SLAMF1, SLAMF6, and SLAMF8 affect development of NKT cells, and CD84, SLAMF7, and SLAMF8 affect the development of innate CD8(+) T cells
  • in NK cells, SLAMF7 signaling induces cytolytic function of NK cells against targets whereas in B cells SLAMF7 induces proliferation and autocrine cytokine production
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • homophilic interaction
  • interacting with a 19kDa tyrosine phosphorylated protein and a 39kDa phosphoprotein
  • coupling of SLAMF7 to INPP5D required SRC kinases, which phosphorylated SLAMF7
  • cell & other
    REGULATION
    induced by CD40 activation on B cells, by influenza virus, lipopolysaccharides and CD40L on dendritic cells
    Other tyrosine phosphorylated in activated NK cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    observed in PTPRC-deficient NK cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    promising antigen that can be targeted by chimeric antigen receptor (CAR) -expressing T cells for treatment of Multiple myeloma
    immunologyautoimmunearticular
    potential of SLAMF7 as a therapeutic target in rheumatoid arthritis
    ANIMAL & CELL MODELS