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FLASH GENE
Symbol SLAMF1 contributors: mct - updated : 16-02-2017
HGNC name signaling lymphocytic activation molecule family member 1
HGNC id 10903
Location 1q23.3      Physical location : 160.579.891 - 160.617.081
Synonym name CD150 antigen
Synonym symbol(s) CDW150, SLAM, CD150, IPO-3
DNA
TYPE functioning gene
STRUCTURE 37.19 kb     7 Exon(s)
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 2009 - 335 - 1999 10229804
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node    
 thymus    
Reproductivefemale systembreastmammary gland  
 female systemplacenta   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmonocyte
Blood/Hematopoieticthymocyte
Lymphoid/ImmuneB cell
Lymphoid/Immunedendritic cell
Lymphoid/ImmuneT cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one immunoglobulin-like C2-type domain
  • one immunoglobulin-like V-type domain
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • CD2 immunoglobulin superfamily
  • SLAM subfamily
  • CATEGORY immunity/defense , regulatory , receptor membrane G
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • transmembrane receptor activity
  • mediates intracellular protein tyrosine phosphorylation signals dependent on the binding affinity to SAP
  • involved in T cell stimulation and cytokine production
  • may play an important role in the regulation of immune responses to pathogens
  • mediate important regulatory signals in immune cells, as a result of their exquisite ability to associate with members of the SLAM-associated protein (SAP) family of adaptors (Veillette 2007)
  • role in the regulation of adaptive and innate immune responses (Calpe 2008)
  • prominent role for SLAM receptor ligation in IL4 production by GC (Germinal center) CD4 T cells but not in T(FH) cell and GC T(FH) cell differentiation (Yusuf 2010)
  • with its receptor modulate T cell functions (Detre 2010)
  • connects the gram-negative bacterial phagosome to ubiquitous cellular machinery responsible for the control of bacterial killing
  • SLAMF1, CD48, CD84, CD244, LY9, SLAMF6, SLAMF7 play an essential and non-redundant role in the control of humoral immune responses
  • SLAMF1 recruits a subset of PIK3C3-associated proteins, which is involved in membrane fusion and CYBB regulation
  • natural killer T (NKT) cells and innate CD8(+) T cell development can be regulated in a SAP-dependent and -independent fashion by SLAMF receptors, in which SLAMF1, SLAMF6, and SLAMF8 affect development of NKT cells, and CD84, SLAMF7, and SLAMF8 affect the development of innate CD8(+) T cells
  • is a member of the CD2 superfamily, a costimulatory lymphocyte receptor, a receptor for measles virus, and a microbial sensor on macrophages
  • cell surface receptor SLAMF1 (CD150) is requisite for optimal NADPH-oxidase (Nox2) dependent reactive oxygen species (ROS) production by phagocytes in response to Gram- bacteria
  • SLAMF1 and SLAMF8 govern ROS-dependent innate immune responses of myeloid cells, thus modulating migration of these cells during inflammation in an opposing manner
  • SLAMF1, CD84, and SLAMF6 are important negative regulators of humoral immune response, consistent with the notion that SLAM family receptors have dual functions in immune responses
  • SLAMF1 and CD180 are involved in regulation of transcription factors expression in chronic lymphocytic leukemia cells (
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text immuno stimulatory function
    PATHWAY
    metabolism
    signaling
    SLAM-SH2D1A signaling pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with SH2 domain protein 1A (SH2D1A) and PTPN11
  • SLAMF1 interacts with the class III PIK3C3 in a complex with BECN1 and UVRAG
  • cell & other
  • receptor for the measles virus, via its V domain
  • REGULATION
    repressed by stimulated by antigen (memory cell)
    Other expression upregulated by IL-1B
    phosphorylated by FYN
    down-regulated on lymphocytes by measles virus
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    in Chronic lymphocytic leukemia (CLL) modulates genetic pathways that regulate chemotaxis and autophagy and that potentially affect drug responses
    constitutional     --over  
    significantly increased expression of SLAMF1 by CD3+CD4+ helper T cells and CD19+ B cells in patients with SLE and active disease
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker new diagnostic marker in CNS tumors
    Therapy target
    SystemTypeDisorderPubmed
    cancerbrain 
    potential target for novel therapeutic approaches in CNS tumors
    ANIMAL & CELL MODELS