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FLASH GENE
Symbol SLA contributors: mct - updated : 29-11-2011
HGNC name Src-like-adaptor
HGNC id 10902
Location 8q24.22      Physical location : 134.048.973 - 134.115.310
Synonym symbol(s) SLA1, SLAP
DNA
TYPE functioning gene
SPECIAL FEATURE opposite orientation
text embedded within the 64 kb intron of the thyroglobulin gene (TG), in opposite orientation
STRUCTURE 66.34 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site
text structure transcriptional regulation by retinoic acid and by activation of B cells
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 3506 - 276 - 2006 17110436
8 - 3228 - 293 - 2006 17110436
7 - 2872 - 316 - 2006 17110436
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid   highly
Lymphoid/Immunespleen   highly
 thymus   highly
Nervousbrain   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain, lung
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • domains homolog to SH2 motif and a proline rich region (SH3 binding domain), lacking a tyrosine catalytic domain
  • unique C terminal region
  • HOMOLOGY
    interspecies homolog to murine Src-like adaptor protein (Slap)
    ortholog to murine Mslap
    Homologene
    FAMILY SRC family of cytoplasmic tyrosine kinase
    CATEGORY adaptor , regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • negative regulator of T-cell receptor signaling
  • functions in a pathway that requires the phosphorylated CD247 and the Src family kinase LCK, but not ZAP70 (zeta-associated protein of 70 kD)
  • SLA and CBL recently have been shown to cooperate in regulating T cell receptor (TCR) levels in developing T cells
  • has a conserved function in B and T cells by adapting CBL to the antigen-receptor complex and targeting it for degradation
  • inhibitor of T- and B-cell receptor signaling
  • negatively regulates differentiation of osteoclasts and proliferation of their precursors
  • SLA and SLA2-mediated CSF2RA regulation is important for the generation of functionally mature monocytic dendritic cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    Eck receptor tyrosine kinase signaling pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding the Eck receptor protein tyrosine kinase
  • glucocorticoid-regulated gene but although SLA is a prominent GC response gene, it does not seem to contribute to the anti-leukemic effects of GC
  • cell & other
    REGULATION
    Other transcriptionally regulated by retinoic acid and by activation of B cells
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS