protein
| interacting with SKP1 (and binding the SCF constant catalytic core ubiquitin ligase) |
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binding to CKS1B, neccessary for binding to phosphorylated CDKN1B |
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interacting with FOXP3 (FOXP3 is a novel transcriptional repressor for the oncogene SKP2) |
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interacting with FOXO1 and promoting its degradation (reversed by proteasome inhibitors) |
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interacting with CDKN1B (interaction negatively regulated by TSC2) |
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target for E2F regulation that is disrupted in several tumor cell lines |
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interacting with CKS1B (binds to and activates cyclin-dependent kinases and also interacts with CKS1B to promote the ubiquitination and proteasomal degradation of CDKN1B) |
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interacts with Akt/protein kinase B (PKB)(directly phosphorylates SKP2, phosphorylation triggering SCF complex formation and E3 ligase activity) |
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interacting with VHL (destabilizes the F-box protein SKP2, a chief component of Skp, Cullin, F-box-containing complex that promotes DNA synthesis in the S phase) |
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is a direct transcriptional target for NR4A1 |
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FOXO3 transcription factor is a novel and negative regulator of SKP2 SCF complex( |
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SKP2-mediatetd NBN ubiquitination is a vital event for ATM activation in response to DNA damage |
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existence of a novel cell cycle-associated, TADA3-regulated signaling pathway that promotes G1/S cell cycle progression by regulating CDKN1B stability through MYC-dependent control of SKP2 expression |
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SIRT3 tumor suppressor serves as the physiological deacetylase that antagonizes EP300-mediated SKP2 acetylation |
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LAMTOR5 was able to stimulate the promoter of SKP2 through binding to the -640/-443 region in SKP2 promoter involving activating E2F transcription factor 1 (E2F1) |
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SF3B3 overexpression reduces the binding of adaptor protein SKP1 and substrate receptor SKP2 to CUL1, whereas it has no effect on CAND1 binding to CUL1 |
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LCK upregulates FOXP3 by tyrosine phosphorylation, resulting in decreased MMP9, SKP2, and VEGFA expression, and suppressed cellular invasion |
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SKP2 may regulate CTNNB1 and its target gene expression to orchestrate hematopoietic stem cell (HSC) homing |
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MYCN bound directly to E-boxes within the SKP2 promoter and induced transcriptional activity which was decreased by the removal of MYCN and E-box mutation |
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YTHDF2 promotes mitotic entry and is regulated by cell cycle mediators (CUL4A, DDB1, CUL1, SKP2) |