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FLASH GENE
Symbol SKOR1 contributors: mct - updated : 19-03-2009
HGNC name SKI family transcriptional corepressor 1
HGNC id 21326
Location 15q23      Physical location : 68.117.940 - 68.126.174
Synonym name
  • ladybird homeobox corepressor 1
  • LBXCOR1 homolog (mouse)
  • transcriptional corepressor CORL1
  • functional smad suppressing element on chromosome 15
  • corepressor for LBX1
  • Synonym symbol(s) CORL1, FUSSEL15, LBXCOR1
    DNA
    TYPE functioning gene
    STRUCTURE 8.23 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 2766 95.9 921 - 2007 17292623
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbraincerebellum   Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    NervousPurkinje cell Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text postmitotic neurons generated posterior to the midbrain-hindbrain border, in the developing spinal cord, selectively expressed in the dorsal horn interneurons
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies homolog to SKI oncoprotein
    Homologene
    FAMILY
  • Ski/Sno proto-oncoproteins family
  • CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text in a nuclear dot-like structure
    basic FUNCTION
  • acting as a transcriptional corepressor for LBX1 in regulating cell fate determination in the dorsal spinal cord
  • neuronal lineage-specific transcriptional corepressor for the homeodomain transcription factor LBX1
  • molecular regulator of BMP signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • LBX1
  • interacts with SMAD1, SMAD2 and SMAD3 molecules and suppresses mainly BMP signaling pathway but has only minor effects on TGF-beta signaling
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS