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FLASH GENE
Symbol SKA3 contributors: mct - updated : 14-01-2016
HGNC name spindle and kinetochore associated complex subunit 3
HGNC id 20262
Location 13q12.11      Physical location : 21.727.734 - 21.750.741
Synonym name
  • chromosome 13 open reading frame 3
  • spindle and kinetochore-associated protein 3
  • Synonym symbol(s) RAMA1, MGC4832, C13orf3
    DNA
    TYPE functioning gene
    STRUCTURE 22.98 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2808 - 388 - 2012 22371557
    9 - 2927 - 412 - 2012 22371557
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
    Reproductivemale systemtestis   
    Urinarybladder    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C-terminal domains of SKA1 and SKA3 protrude at each end of the homodimer, bind microtubules when connected to the central core, and are essential
  • HOMOLOGY
    interspecies ortholog to murine F630043A04Rik
    Homologene
    FAMILY
  • SKA3 family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,chromatin/chromosome,kinetochore
    text
  • localizes to centrosomes, mitotic spindle, kinetochores during cell division
  • localizes to the spindle and to outer kinetochores throughout all phases of mitosis and is recruited to kinetochores by the core kinetochore-microtubule attachment factor HEC1
  • SKA3 protein accumulation at kinetochores in prometaphase is dependent on SGOL1 protein
  • basic FUNCTION
  • SKA3 functions to coordinate checkpoint signaling from the microtubule binding sites within a kinetochore by laterally linking the individual binding sites
  • is required for centrosome integrity and anaphase onset
  • important factor for metaphase to anaphase progression
  • SKA complex functionally complements the KMN network (CASC5, MIS12, NDC80), providing an additional layer of stability to kinetochore-microtubule attachment and possibly signalling completion of attachment to the spindle checkpoint
  • is a novel kinetochore protein, suggesting that SKA3 may have a direct role in mediating kinetochore-microtubule interactions
  • SKA1, SKA2 and SKA3 are required for stabilizing kinetochore-microtubule (KT-MT) interactions and silencing spindle checkpoint during mitosis
  • CELLULAR PROCESS cell cycle, division
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of the Ska complex, an essential mitotic component required for accurate cell division in human cells
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • direct interaction with a regulatory subunit of the PP2A
  • cell & other
    REGULATION
    Other phosphorylated during mitosis (Theis 2009)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS