Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SKA2 contributors: npt/mct - updated : 14-01-2016
HGNC name spindle and kinetochore associated complex subunit 2
HGNC id 28006
Location 17q22      Physical location : 57.187.307 - 57.232.800
Synonym name
  • hypothetical protein LOC348235
  • family with sequence similarity 33, member A
  • protein FAM33A
  • Synonym symbol(s) FLJ12758, MGC110975, FAM33A
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head
    text riented in a head-to-head configuration with its neighboring gene, PRR11
    STRUCTURE 45.49 kb     4 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2990 - 121 - 2006 17093495
    3 - 2988 - 75 - 2006 17093495
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   predominantly
    Reproductivefemale systemuteruscervix highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connective    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine 1110001A07Rik
    Homologene
    FAMILY
  • SKA2 family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus,chromatin/chromosome,kinetochore
    basic FUNCTION
  • involved in mitosis (Rice 2008)
  • SKA complex functionally complements the KMN network (CASC5, MIS12, NDC80) providing an additional layer of stability to kinetochore-microtubule attachment and possibly signalling completion of attachment to the spindle checkpoint
  • SKA1, SKA2 and SKA3 are required for stabilizing kinetochore-microtubule (KT-MT) interactions and silencing spindle checkpoint during mitosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • SKA1 and SKA2 form a complex at the kinetochore-microtubule (KT-MT) interface and are required for timely progression from metaphase to anaphase
  • component of the Ska complex, an essential mitotic component required for accurate cell division in human cells
  • INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with NR3C1 in cancer cells (Rice 2008)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    expression of both PRR11 and SKA2 was significantly upregulated in lung cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS