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FLASH GENE
Symbol SKA1 contributors: mct - updated : 14-01-2016
HGNC name spindle and kinetochore associated complex subunit 1
HGNC id 28109
Location 18q21.2      Physical location : 47.901.391 - 47.920.534
Genatlas name spindle and KT (kinetochore) associated 1
Synonym name
  • chromosome 18 open reading frame 24
  • Synonym symbol(s) C18orf24, MGC10200
    DNA
    TYPE functioning gene
    STRUCTURE 19.15 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text Variants 1 and 2 encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2938 29.5 255 - 2014 24413531
    7 - 2893 29.5 255 - 2014 24413531
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C-terminal domains of SKA1 and SKA3 protrude at each end of the homodimer, bind microtubules when connected to the central core, and are essential
  • HOMOLOGY
    Homologene
    FAMILY
  • SKA1 family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • SKA complex functionally complements the KMN network (CASC5, MIS12, NDC80) providing an additional layer of stability to kinetochore-microtubule attachment and possibly signalling completion of attachment to the spindle checkpoint
  • SKA1, SKA2 and SKA3 are required for stabilizing kinetochore-microtubule (KT-MT) interactions and silencing spindle checkpoint during mitosis
  • critical role of the Ska complex in maintaining a firm grip on dynamic microtubules
  • microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation
  • is required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • SKA1 and SKA2 form a complex at the kinetochore-microtubule (KT-MT) interface and are required for timely progression from metaphase to anaphase
  • component of the Ska complex, an essential mitotic component required for accurate cell division in human cells
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • AURKB phosphorylation antagonizes the interaction between the SKA complex and the KMN network (named according to the acronym for KNL1, MIS12, and NDC80), thereby controlling SKA recruitment to kinetochore (KT) and stabilization of KT-MT attachments
  • integrated kinetochore-microtubule interface formed by the SKA1 and NDC80 complexes that associates with depolymerizing microtubules, potentially by interacting with curved microtubule protofilaments
  • kinetochore-associated SKA complex interacts with tubulin monomers via the C-terminal winged-helix domain of SKA1, providing the structural basis for the ability to bind both straight and curved microtubule structures
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in gastric cancer tissues
    tumoral     --over  
    promotes prostate tumourigenesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • SKA1 could be used for gastric cancer early diagnosis as a biomarker
  • Therapy target
    ANIMAL & CELL MODELS