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FLASH GENE
Symbol SIT1 contributors: npt - updated : 09-12-2002
HGNC name signaling threshold regulating transmembrane adaptor 1
HGNC id 17710
Location 9p13-p12      Physical location : 35.649.296 - 35.650.947
Synonym name
  • SH2P interacting transmembrane adaptor
  • suppression inducing transmembrane adaptor 1
  • Synonym symbol(s) MGC125908, MGC125909, MGC125910, RP11-331F9.5, SIT, gp30/40
    DNA
    TYPE functioning gene
    STRUCTURE 1.00 kb     5 Exon(s)
    regulatory sequence Promoter
    Binding site
    text structure binding sites for both ubiquitous and lympho
    d specific transcription factors
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1238 21 196 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   lowly
     thymus   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage T cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 22 hydrophobic leader peptide
  • 18 AA extracellular domain containing a potential N glycosylation site
  • a cysteine residue involved in an interchain disulfide bond
  • 20 AA transmembrane domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS