Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SIRT7 contributors: mct - updated : 24-01-2015
HGNC name sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae)
HGNC id 14935
Location 17q25.3      Physical location : 79.869.814 - 79.876.058
Synonym name
  • silent mating type information regulation 2, S.cerevisiae, homolog 7
  • sir2-related protein type 7
  • sirtuin 7
  • Synonym symbol(s) SIR2L7, MGC126840, MGC126842
    EC.number 3.5.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 6.24 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    OCSP 17q25.3 oculospanin PDE6G 17q21.1 phosphodiesterase 6G, cGMP-specific, rod, gamma LOC339229 17q25.3 hypothetical protein LOC339229 MGC16597 17q25.3 similar to RIKEN cDNA 3110023B02 LOC339231 17q25.3 hypothetical protein LOC339231 HGS 17q25 hepatocyte growth factor-regulated tyrosine kinase substrate MRPL12 17q25 mitochondrial ribosomal protein L12 SLC25A10 17q25.3 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 LOC388432 17 similar to dysferlin-interacting protein 1 P4HB 17q25.2 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide (protein disulfide isomerase; thyroid hormone binding protein p55) ARHGDIA 17q25.3 Rho GDP dissociation inhibitor (GDI) alpha THOC4 17q25.3 THO complex 4 ANAPC11 17q25.3 APC11 anaphase promoting complex subunit 11 homolog (yeast) NPB 17q25.3 preproneuropeptide B LOC388433 17 LOC388433 PCYT2 17q25.3 phosphate cytidylyltransferase 2, ethanolamine SIRT7 17q25 sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae) MGC13090 17q25.3 hypothetical protein MGC13090 MAFG 17q25 v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian) LOC92659 17q25.3 hypothetical protein BC009233 PYCR1 17q25.3 pyrroline-5-carboxylate reductase 1 LOC255275 17q25.3 similar to myeloid-associated differentiation marker LOC147111 17q25.3 hypothetical protein LOC147111 ASPSCR1 17q25 alveolar soft part sarcoma chromosome region, candidate 1 STRA13 17q25.3 stimulated by retinoic acid 13 MGC20806 17q25.3 hypothetical protein MGC20806 RAC3 10q25.3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) DCXR 17q25.3 dicarbonyl/L-xylulose reductase GPS1 17q25.3 G protein pathway suppressor 1 PP3111 17q25.3 PP3111 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1749 - 400 - Ashraf (2006)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Endocrinepancreas   predominantly
    Reproductivefemale systemuteruscervix highly
     female systemovary  highly
     female systemplacenta  highly
     male systemtestis  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a deacetylase sirtuin-type core domain
  • HOMOLOGY
    interspecies homolog to yeast Sir2
    ortholog to rattus Sirt7 predicted
    homolog to murine Sirt7
    homolog to Drosophila sirt7
    Homologene
    FAMILY sirtuin family, class IV
    CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    intracellular,nucleus,nucleolus
    text
  • located under the nuclear membrane
  • existence of a cytoplasmic pool of SIRT7 in addition to its well-known nucleolar form
  • basic FUNCTION
  • NAD(+) ADP ribosyltransferase with a protein deacetylase activity
  • acting via the formation of large multiprotein complexes that are responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4)
  • positive regulator of RNA polymerase I (Pol I) transcription and is required for cell viability in mammals
  • by participating in the stress response to genomic insults, sirtuins are thought to protect against cancer, but they are also emerging as direct participants in the growth of some cancers (Saunders 2007)
  • involved in resumption of rDNA transcription at the exit from mitosis
  • may enable cells to sustain critical metabolic functions by inhibiting cell growth even under severe stress conditions
  • is an NAD+-dependent H3K18Ac (acetylated lysine 18 of histone H3) deacetylase that stabilizes the transformed state of cancer cells
  • pivotal role for SIRT7 in chromatin regulation, cellular transformation programs and tumour formation
  • association between loss of nucleolar SIRT7 and replicative senescence
  • novel molecular function of SIRT7 as a negative regulator of HIF signaling
  • is involved in multiple pathways involved in ribosome biogenesis, and potentially its down-regulation may contribute to an antitumor effect, partly through the inhibition of protein synthesis
  • participates in rDNA transcription in the nucleolus
  • is at the crossroads of chromatin signaling, metabolic, and tumor-regulatory pathways
  • hepatic SIRT7 controls lipid metabolism in liver by regulating the ubiquitin-proteasome pathway
  • is a crucial regulator of mitochondrial homeostasis
  • attenuates DNA damage, SAPK activation and TP53 response thereby promoting cellular survival under conditions of genomic stress
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS electron transport
    text
  • protein ADP-ribosylation
  • chromatin silencing
  • proline biosynthesis
  • PATHWAY
    metabolism aminoacid
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • Zn2+
  • protein
  • ELK4 functions to target SIRT7 to specific promoters for H3K18 deacetylation
  • MYBBP1A binds to SIRT7, and is a novel negative regulator of SIRT7
  • vassociates with chromatin, where it catalyzes selective deacetylation of lysine 18 on histone H3 (H3K18), an emerging epigenetic biomarker of aggressive tumors and poor clinical outcome in patients with cancer
  • is a dynamic nuclear regulator of mitochondrial function through its impact on GABPB1 function
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    overexpressed in human thyroid carcinoma cell lines and tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    is a promising pharmacologic target for epigenetic cancer therapy
    ANIMAL & CELL MODELS
  • Sirt7 deficiency in mice induces multisystemic mitochondrial dysfunction, which is reflected by increased blood lactate levels, reduced exercise performance, cardiac dysfunction, hepatic microvesicular steatosis, and age-related hearing loss
  • suppresses ER stress and reverts the fatty liver disease in diet-induced obese mice