basic FUNCTION
| being a NAD(+) ADP ribosyltransferase with a protein deacetylase activity |
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a nuclear, chromatin-associated protein that promotes resistance to DNA damage and suppresses genomic instability in association with a role in base excision repair ( |
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by participating in the stress response to genomic insults, sirtuins are thought to protect against cancer, but they are also emerging as direct participants in the growth of some cancers |
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an NAD+-dependent, histone H3 lysine 9 (H3K9) deacetylase that modulates telomeric chromatin ( |
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plays critical roles in intermediary metabolism and genomic stability |
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NAD-dependent deacetylases promoting longevity |
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functions at chromatin to attenuate NF-KB signaling, via H3K9 deacetylation at chromatin |
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inhibits expression of a subset of NF-KB target genes, especially those associated with aging |
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modulates apoptosis resistance and telomere-independent cellular senescence in human cells, via inhibition of NF-KB |
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important for DNA repair, transcriptional regulation of genes important for metabolism and immune responses, and for lifespan |
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forms a macromolecular complex with the DNA double-strand break (DSB) repair factor PRKDC (DNA-dependent protein kinase) and promotes DNA DSB repair |
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function as a corepressor of the transcription factor HIF1A, a critical regulator of nutrient stress responses |
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functions as a histone H3K9 deacetylase to control the expression of multiple glycolytic genes ( |
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functions as a corepressor of the transcription factor Hif1alpha, a critical regulator of nutrient stress responses ( |
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a master regulator of glucose homeostasis ( |
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plays a critical role in fat metabolism |
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has a role in promoting DNA end resection, a crucial step in DNA double-strand break (DSB) repair by homologous recombination |
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essential role of SIRT6 in modulating glucose metabolism through mediating insulin sensitivity |
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functions as a central regulator of somatic growth and plays an important role in preventing obesity by modulating neural chromatin structure and gene activity |
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major H3K9 and H3K56 deacetylase in the brain, suggesting potential roles in regulation of gene activity |
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neural SIRT6 as a regulator of the somatic growth axis and a potential disease factor for adult-onset obesity |
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having a poor deacetylase activity (a less stable substrate-protein interaction might be the cause of this poor deacetylase activity) |
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displays tight binding of NAD+ in the absence of an acetylated substrate |
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could be able to bind NAD+ in the absence of an acetylated substrate |
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might ensure metabolic homeostasis and promote more efficient energy usage through its ability to sense the levels of NAD+ (and related metabolites) and regulate protein-protein interactions with transcription factors |
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recruited to the sites of DNA double-strand breaks (DSBs) and stimulates DSB repair under oxidative stress ( |
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activation provides a potential therapeutic strategy to prevent the decline in genome maintenance |
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is a tumor suppressor that regulates aerobic glycolysis in cancer cells |
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SIRT6 expression is downregulated in human cancers, strongly reinforcing the idea that SIRT6 is a novel tumor suppressor |
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is likely a tumor suppressor involved in both cancer initiation and tumor growth |
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represses tumorigenesis by inhibiting a glycolytic switch required for cancer cell proliferation |
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promotes the secretion of tumour necrosis factor-alpha(TNF) by removing the fatty acyl modification on K19 and K20 of TNF |
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important role of hepatic SIRT6 and FOXO3 in the regulation of cholesterol homeostasis |
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preferentially hydrolyze long-chain fatty acyl groups over acetyl groups |