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FLASH GENE
Symbol SIRPG contributors: - updated : 01-04-2006
HGNC name signal-regulatory protein gamma
HGNC id 16247
Location 20p13      Physical location : 1.609.797 - 1.638.425
Synonym name
  • signal regulatory protein (SIRP) homolog beta 2
  • signal-regulatory protein beta 2
  • Synonym symbol(s) SIRP-B2, CD172g, SIRPB2, SIRP-B2, bA77C3.1, SIRPgamma
    DNA
    TYPE functioning gene
    STRUCTURE 28.00 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen    
     thymus    
    Reproductivemale systemtestis   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a transmembrane short intracellular domain
  • putative signal sequence
  • a long extracellular domain
  • three immunoglobulin (Ig) domain
  • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to SIRPB1
    Homologene
    FAMILY SIRP/SHPS-1 protein family
    CATEGORY signaling , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein like PTPNS1, it binds CD47(SIRPG-CD47 interaction may therefore not be capable of bidirectional signaling as with the PTPNS1-CD47, but, instead, use unidirectional signaling via CD47 only)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS