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FLASH GENE
Symbol SIPA1L1 contributors: mct - updated : 08/10/2008
HGNC name signal-induced proliferation-associated 1 like 1
HGNC id 20284
Location 14q24.2      Physical location : 71.996.041 - 72.206.118
Genatlas name signal-induced proliferation-associated 2
Synonym name
  • signal-induced proliferation-associated 1-like 1
  • spine-associated Rap-Gap (SPAR)
  • Synonym symbol(s) KIAA0440, SPA1L, SPA1H2 , E6TP1, SIPA2, SPAR
    DNA
    TYPE functioning gene
    STRUCTURE 210.08 kb     22 Exon(s)
    MAPPING cloned Y linked   status confirmed
    Physical map
    SFRS5 14q24 splicing factor, arginine/serine-rich 5 SLC10A1 14q24.1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 SMOC1 14q24.1 SPARC related modular calcium binding 1 RPL7AP6 14 ribosomal protein L7a pseudogene 6 SLC8A3 14q24.1 solute carrier family 8 (sodium-calcium exchanger), member 3 LOC387995 14 similar to leucin rich neuronal protein ADAM21P 14q24.1 a disintegrin and metalloproteinase domain 21 pseudogene LOC338914 14q24.1 hypothetical LOC338914 C14orf112 14q24.1 chromosome 14 open reading frame 112 SYNJ2BP 14q22.1-q24.3 synaptojanin 2 binding protein ADAM21 14q24.1 a disintegrin and metalloproteinase domain 21 C14orf55 14 chromosome 14 open reading frame 55 ADAM20 14q24.1 a disintegrin and metalloproteinase domain 20 MED6 14q24.1 mediator of RNA polymerase II transcription, subunit 6 homolog (yeast) TTC9 14q24.1 tetratricopeptide repeat domain 9 MAP3K9 14q24.3-q31 mitogen-activated protein kinase kinase kinase 9 PCNX 14q24.2 pecanex homolog (Drosophila) PTTG4P 14 pituitary tumor-transforming 4 pseudogene LOC387997 14 LOC387997 LOC390492 14 similar to GWSC6486 SIPA1L1 14q24.1 signal-induced proliferation-associated 1 like 1 RGS6 14q24.3 regulator of G-protein signalling 6 DPF3 14q24.3-q31.1 D4, zinc and double PHD fingers, family 3 WDR21 14q24.3 WD repeat domain 21 RPL36AP3 14 ribosomal protein L36a pseudogene 3 RPS12P1 14 ribosomal protein S12 pseudogene 1 ZFYVE1 14q22-q24 zinc finger, FYVE domain containing 1 RNPC7 14q24.3 RNA-binding region (RNP1, RRM) containing 7 PSEN1 14q24.3 presenilin 1 (Alzheimer disease 3)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 6028 - 1804 - Olsen (2006)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Endocrineneuroendocrinepituitary  highly
    Lymphoid/Immunelymph node   highly
     spleen   highly
    Nervousbrain    
     spinal cord    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one PDZ/DHR domain
  • one RAP-GAP domain
  • HOMOLOGY
    interspecies homolog to murine Spa-1 2
    homolog to C.elegans T27F2.2
    homolog to rat Spar
    Homologene
    FAMILY
    CATEGORY signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    basic FUNCTION
  • GTPase-activating protein specific for Rap1 and Rap2, postsynaptic actin regulatory protein
  • involved in actin remodeling, RAP signaling, and spine morphogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SNK
  • binding to HPV 16 E6
  • cell & other
    REGULATION
    Other degraded by SNK
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS