SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,nucleus
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text
| SIK2 co-localizes with VCP in the ER membrane |
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localizes at the centrosome |
basic FUNCTION
| protein serine/threonine kinase activity |
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SIK2-CRTC2 cascade may be important for the regulation of PPARGC1A and UCP1 gene expression in insulin signaling in brown adipose tissue (BAT) |
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SIK2 plays a key role in the initiation of mitosis, and regulates the localization of the centrosome linker protein, CEP250, through S2392 phosphorylation |
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function in the insulin-signaling pathway during adipocyte differentiation and to modulate CREB-mediated gene expression in response to hormones and nutrients |
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is a critical determinant in autophagy progression, suggesting a mechanism in which the interplay among kinase and deacetylase activities contributes to cellular protein pool homeostasis |
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SIK2 activates MEF2-dependent transcription and relieves repression of myogenesis by the deacetylases |
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could serve likely a similar role during the development of diabetic retinopathy |
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SIK2 is shown to be stabilized in pancreatic beta-cells following glucose stimulation, leading to improved systemic glucose homeostasis by regulating cellular calcium flux and insulin secretion |
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SIK2 is critical in regulating whole-body glucose metabolism primarily by controlling the CRTC2-CREB function of the white adipocytes |
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regulates mitotic progression and transcription in prostate cancer |
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plays a role in CREB1-mediated gene transcription |
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SIK3, rather than SIK1, SIK2, or AMPKs, acts as the predominant suppressor in gluconeogenic gene expression in the hepatocytes |
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disrupts EP300-PPARA interaction by direct phosphorylation of EP300 at Ser89, which in turn decreases PPARA-mediated ketogenic gene expression |