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FLASH GENE
Symbol SIGLEC9 contributors: mct/npt - updated : 19-01-2013
HGNC name sialic acid binding Ig-like lectin 9
HGNC id 10878
Location 19q13.41      Physical location : 51.628.164 - 51.633.566
Synonym name
  • OB binding protein-like
  • protein FOAP-9
  • Synonym symbol(s) OBBP-like, CD329, CDw329, FOAP-9
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text in a cluster with other SIGLEC3-like genes on 19q13.4
    STRUCTURE 11.38 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - KLK1 - KLK3 - KLK2 - KLK4 - KLK5 - KLK6 - KLK7 - KLK8 - KLK9 - KLK10 -KLK11 - KLK12 - KLK13 - KLK14 - SIGLEC9 - qter
    Authors Foussias (00)
    regionally located clustering with SIGLEC3/CD33 related subset on SIGLECs on chromosome 19, telomeric to the KLK cluster
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1737 50.1 463 - Zhang, Ando (2008)
    - - - 3300 - - placenta Zhang
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Digestivepharynx    
     stomach    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmonocyte
    Blood/Hematopoieticneutrophil
    Blood/HematopoieticNK cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text placenta, liver
    PROTEIN
    PHYSICAL PROPERTIES Hydrophobic
    STRUCTURE
    motifs/domains
  • three extracellular immunoglobulin-like domains
  • a N terminal V-set and two proximal C2-Set domains
  • a transmembrane region
  • a cytoplasmic tail containing two putative tyrosine-based signaling motifs, the proximal fitting the immunoreceptor tyrosine base inhibitory motif (ITIM), critical for the inhibitory signaling mediated
  • light potential N-linked glycosylation sites
  • conjugated GlycoP
    HOMOLOGY
    intraspecies homolog to SIGLEC5,SIGLEC7,SIGLEC8,CD33
    Homologene
    FAMILY
  • sialoadhesin family
  • immunoglobulin superfamily
  • CATEGORY antigen , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • mediating sialic acid-dependent binding to red cells and glycoconjugates
  • "CD33"-related siglecs expressed on natural killer (NK) cells and subsets of peripheral T cells
  • capable of negative regulation of TCR signaling and ligand binding is required for optimal activity
  • initiating apoptotic (ROS- and caspase-dependent) and nonapoptotic (ROS-dependent) death pathways in neutrophils
  • enhances the production of the anti-inflammatory cytokine IL10 in macrophages
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    text tumoral cells
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • recognize sialic acid-containing glycans of glycoproteins and glycolipids as ligands
  • induce cell death in adult polymorphonuclear neutrophils in association with PTPN6
  • physically interact with PTPN6, and age-specific interactions between SIGLEC9 and PTPN6 may influence the altered inflammatory responsiveness and longevity of neonatal polymorphonuclear neutrophils
  • MUC16-SIGLEC9 binding likely mediates inhibition of anti-tumor immune responses
  • binding between SIGLEC9 and AOC3 (is a novel leukocyte ligand for AOC3and can be used in PET imaging of inflammation and cancer)
  • MUC16 intreracting with SIGLEC9
  • SIGLEC9 expressed on immune cells may play a role as a potential counterreceptor for MUC1 and this signaling may be another MUC1-mediated pathway and function in parallel with a growth factor-dependent pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS