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FLASH GENE
Symbol SIGLEC8 contributors: mct - updated : 07-05-2008
HGNC name sialic acid binding Ig-like lectin 8
HGNC id 10877
Location 19q13.41      Physical location : 51.954.251 - 51.961.708
Synonym name
  • sigloadhesin family member 2
  • sialic acid-binding Ig-like lectin 8
  • CD329 antigen
    • Synonym symbol(s) SAF2, SIGLEC8L, MGC59785, SIGLEC-8, CDw329
    DNA
    TYPE functioning gene
    STRUCTURE 7.46 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    regionally located clustering with SIGLEC3/CD33 related subset on SIGLECs on chromosome 19
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 2967 - 499 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Connective    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticeosinophil
    not specificmast cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four extracellular Ig-like domains
  • a short cytoplasmic tail with immunoreceptor tyrosine-based inhibitory motifs
  • C terminus with 2 tyrosine - based motifs homologous CD33 like SIGLEC
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • SIGLEC (sialic acid binding Ig-like lectin) family
    • CATEGORY antigen , receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type 1 membrane protein
    basic FUNCTION
  • mediating sialic-acid dependent cell-cell interactions between neuronal and myelinating cells
  • Siglec-8-induced apoptosis occurs through the sequential production of ROS, followed by induction of mitochondrial injury and caspase cleavage
  • plays a distinctive and important role in regulating eosinophil accumulation and survival
  • selectively expressed on eosinophil surfaces and regulates eosinophil survival, preferentially binds to the glycan 6'-sulfo-sialyl Lewis X (6'-sulfo-sLe(x)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to asthma
    Variant & Polymorphism SNP SNP rs6509541 associated with susceptibility to asthma
    Candidate gene
    Marker
    Therapy target
  • Siglec-8 activation may provide a useful therapeutic approach to reduce numbers of eosinophils (and perhaps basophils and mast cells) in disease states where these cells are important
    • ANIMAL & CELL MODELS