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FLASH GENE
Symbol SIGLEC6 contributors: npt/ - updated : 23-01-2007
HGNC name sialic acid binding Ig-like lectin 6
HGNC id 10875
Location 19q13.3      Physical location : 52.022.783 - 52.035.110
Synonym name
  • cell differentiation antigen CD33-like 1
  • CD33 antigen-like 1
  • CD327 antigen
  • obesity-binding protein 1
  • Synonym symbol(s) OB-BP1, CD33L1, CD33L, SIGLEC-6, CD327, CDw327
    DNA
    TYPE functioning gene
    STRUCTURE 12.08 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    CD33 19q13.3 CD33 antigen (gp67) FLJ40235 19q13.41 hypothetical protein FLJ40235 LOC339351 19q13.41 similar to hypothetical protein LOC162952 19q13.41 similar to Opioid binding protein/cell adhesion molecule precursor (OBCAM) (Opioid-binding cell adhesion molecule) (OPCML) LOC147645 19q13.41 hypothetical protein LOC147645 ETFB 19q13.4 electron-transfer-flavoprotein, beta polypeptide MGC33839 19q13.41 hypothetical protein MGC33839 NKG7 19q13.4 natural killer cell group 7 sequence LIM2 19q13.4 lens intrinsic membrane protein 2, 19kDa LOC147646 19q13.41 hypothetical protein LOC147646 LOC388557 19 similar to nucleolar phosphoprotein Nopp34 SIGLEC10 19q13.3 sialic acid binding Ig-like lectin 10 SIGLEC8 19q13.33-q13.41 sialic acid binding Ig-like lectin 8 SIGLECL1 19q13.4 SIGLEC-like 1 SIGLEC6 19q13.3 sialic acid binding Ig-like lectin 6 ZNF175 19q13.4 zinc finger protein 175 LOC147649 19q13.41 hypothetical LOC147649 LOC339352 19q13.41 hypothetical LOC339352 SIGLEC5 19q13.4 sialic acid binding Ig-like lectin 5 LOC147650 19q13.41 hypothetical protein LOC147650 HAS1 19q13.3-q13.4 hyaluronan synthase 1 FPR1 19q13.4 formyl peptide receptor 1 FPRL1 19q13.4 formyl peptide receptor-like 1
    regionally located clustering with SIGLEC3/CD33 related subset on SIGLECs on chromosome 19
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 2076 - 453 - -
    - - 2028 - 437 - -
    - - 1900 - 353 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Digestiveintestinesmall intestine   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    Lymphoid/ImmuneB cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • three Ig-like domains
  • a cytoplasmic tail
  • two immunoreceptor tyrosine based inhibitory motifs (ITIM) the second of these motifs matching a sequence found in (signaling lymphocyte activating molecule) SLAM and SLAM-like protein
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • SIGLEC (sialic acid binding Ig-like lectin) family
  • CATEGORY antigen , receptor
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • mediating cell-cell recognition
  • also binding leptin and potentially modulator of leptin levels
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • protein constituent of transmembrane
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • leptin binding
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS