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FLASH GENE
Symbol SIGLEC5 contributors: mct - updated : 23-01-2007
HGNC name sialic acid binding Ig-like lectin 5
HGNC id 10874
Location 19q13.4      Physical location : 52.114.781 - 52.133.727
Synonym name
  • cell differentiation antigen CD33-like 2
  • obesity-binding protein 2
  • CD170 antigen
  • Synonym symbol(s) CD33L2, OB-BP2, OBBP2, CD170, SIGLEC-5
    DNA
    TYPE functioning gene
    STRUCTURE 18.95 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map cen - D19S425 - COX6B1 - D19S208 - D19S224 - SCN1B - D19S228 - LGALS7 - D19S421 - RPS16 - MST1 - D19S223 - RPS19 - D19S217 - ERCC1 - D19S219 - D19S606 - FUT1 - SNRP70 - D19S907 - SIGLEC5 - FPRL1 - D19S571 - D19S927 - D19S418 - qter
    Authors GeneMap (98)
    Physical map
    FLJ40235 19q13.41 hypothetical protein FLJ40235 LOC339351 19q13.41 similar to hypothetical protein LOC162952 19q13.41 similar to Opioid binding protein/cell adhesion molecule precursor (OBCAM) (Opioid-binding cell adhesion molecule) (OPCML) LOC147645 19q13.41 hypothetical protein LOC147645 ETFB 19q13.4 electron-transfer-flavoprotein, beta polypeptide MGC33839 19q13.41 hypothetical protein MGC33839 NKG7 19q13.4 natural killer cell group 7 sequence LIM2 19q13.4 lens intrinsic membrane protein 2, 19kDa LOC147646 19q13.41 hypothetical protein LOC147646 LOC388557 19 similar to nucleolar phosphoprotein Nopp34 SIGLEC10 19q13.3 sialic acid binding Ig-like lectin 10 SIGLEC8 19q13.33-q13.41 sialic acid binding Ig-like lectin 8 SIGLECL1 19q13.4 SIGLEC-like 1 SIGLEC6 19q13.3 sialic acid binding Ig-like lectin 6 ZNF175 19q13.4 zinc finger protein 175 LOC147649 19q13.41 hypothetical LOC147649 LOC339352 19q13.41 hypothetical LOC339352 SIGLEC5 19q13.4 sialic acid binding Ig-like lectin 5 LOC147650 19q13.41 hypothetical protein LOC147650 HAS1 19q13.3-q13.4 hyaluronan synthase 1 FPR1 19q13.4 formyl peptide receptor 1 FPRL1 19q13.4 formyl peptide receptor-like 1 FPRL2 19q13.3-q13.4 formyl peptide receptor-like 2 LOC390957 19 similar to Zinc finger protein 84 (Zinc finger protein HPF2) MGC4400 19q13.41 hypothetical protein MGC4400 FLJ12644 19q13.41 hypothetical protein FLJ12644 LOC390958 19 similar to ZNF84 protein FLJ13590 19q13.41 hypothetical protein FLJ13590
    regionally located clustering with SIGLEC3/CD33 related subset on SIGLECs on chromosome 19
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 splicing 2498 - 551 - 1998 9731071
    - - - - - - 2002 12358929
  • also called SIGLEC5 3L
  • one long cytoplasmic tail and three extracellular domains
  • - - - - - - 2002 12358929
  • also called SIGLEC5 3C
  • soluble isoform with three extracellular domains
  • - - - - - splen,thymus,lymph node,peripheral leukocytes,bone marrow,fetal lung and liver 2002 12358929
  • also called SIGLEC5 4L
  • long cytoplasmic tail and four extracellular domains
  • - - - - - - 2002 12358929
  • also called SIGLEC5 4S
  • short tail and four extracellular domains
  • EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx    
    Lymphoid/Immunespleen    
    Urinarybladder    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticneutrophil
    cell lineage myeloid cells lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two tyrosine-based motifs in its cytoplasmic tail implicated in signaling functions
  • four Ig-like domains
  • three immunoglobulin-like C2-type domains
  • one immunoglobulin-like V-type domain
  • one N-terminal IgV-SET domain
  • three IgC2-SET domains
  • a cytoplasmic domain with ITIM (immunoreceptor tyrosine based inhibitory) motifs forming disulfide-linked homodimers and SAP motifs which regulate cell signaling
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • SIGLEC (sialic acid binding Ig-like lectin) family
  • CATEGORY adhesion , antigen , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • putative adhesion molecule mediating sialic-acid dependent binding to cells
  • playing a role in cell/cell interactions following microbial exposure
  • can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation
  • plays a distinctive and important role in regulating eosinophil accumulation and survival
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • member of CD33-related siglec subgroup of sialic acid binding Ig-like lectins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in acute myeloid leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS