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FLASH GENE
Symbol SIGLEC15 contributors: mct - updated : 03-05-2016
HGNC name sialic acid binding Ig-like lectin 15
HGNC id 27596
Location 18q12.3      Physical location : 43.405.544 - 43.422.521
Synonym name
  • CD33 antigen-like 3
  • CD33 molecule-like 3
  • Synonym symbol(s) HsT1361, CD33L3, SIGLEC-15
    DNA
    TYPE functioning gene
    STRUCTURE 16.98 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1523 35 328 - 2007 17483134
    EXPRESSION
    Rna function
  • mRNA expression increased in association with osteoclast differentiation
  • Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Lymphoid/Immunespleen    
    Skeleton      Homo sapiens
    Skin/Tegumentskin    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunedendritic cell Homo sapiens
    Lymphoid/Immunemacrophage Homo sapiens
    Skeletonosteoclast Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two immunoglobulin (Ig)-like domains
  • a transmembrane domain containing a lysine residue
  • a short cytoplasmic tail
  • HOMOLOGY
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • SIGLEC (sialic acid binding Ig-like lectin) family, of glycan-recognition proteins
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    text is localized to the plasma membrane
    basic FUNCTION
  • functioning as an activating signaling molecule
  • may be playing a regulatory role in the immune system
  • plays an important role in osteoclast differentiation
  • may play a role mainly in osteoclast cell fusion, the terminal process in osteoclast differentiation
  • is required for multinucleated osteoclast formation, actin rearrangement in multinucleated cells, and bone resorbing activity in a TYROBP-dependent manner
  • plays an important role in physiologic bone remodeling by modulating TNFSF11 signaling, especially in the secondary spongiosa
  • is involved in estrogen deficiency-induced differentiation of osteoclasts
  • immunoreceptor that regulates osteoclast development and bone resorption in association with TYROBP
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • SIGLEC15-TYROBP-SYK-signaling cascade plays a critical role in functional osteoclast formation
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associates with the activating adaptor proteins DNAX activation protein DAP12 and DAP10 via its lysine residue in the transmembrane domain
  • in a similar fashion to cathepsin K and TRAP, its expression was markedly up-regulated by TNFSF11 stimulation in the cells
  • links TNFSF11-TNFSFR11-NFATC1 signaling with ITAM-mediated intracellular signaling cascades during functional osteoclast development
  • SIGLEC15 is a TYROBP-associated receptor in osteoclasts
  • regulates osteoclast development and bone resorption by modulating receptor activator of TNFSF11 signaling in association with TYROBP
  • immunoreceptor that regulates osteoclast development and bone resorption in association with an immunoreceptor tyrosine-based activation motif (ITAM) adaptor protein (TYROBP)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in giant cell tumor of bone
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    osteoarticularbone 
    therapeutics target, such as antibody medication for the treatment of metabolic bone diseases
    osteoarticularboneostéoporosis
    potential therapeutic target for postmenopausal osteoporosis
    immunologyinflammatory 
    therapeutic target for periarticular bone loss, but not for joint destruction, in inflammatory arthritis, such as rheumatoid arthritis
    ANIMAL & CELL MODELS