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FLASH GENE
Symbol SIGLEC12 contributors: mct - updated : 12-05-2012
HGNC name sialic acid binding Ig-like lectin 12
HGNC id 15482
Location 19q13.41      Physical location : 51.994.612 - 52.005.043
Synonym name
  • sialic acid-binding immunoglobulin-like lectin-like gene
  • myelo
  • d inhibitory siglec
  • SIGLEC-like 1
  • CD33-related Siglec
  • Synonym symbol(s) S2V, MIS, SLG, SIGLECL1, Siglec-XII, UNQ9215/PRO34042, FLJ38600
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text in a cluster with other SIGLEC3-like genes on 19q13.4
    STRUCTURE 10.43 kb     8 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 splicing 1730 - 477 highly in adrenal gland 2002 11943481
  • SIGLEC-L1S
  • 8 splicing 2126 65 595 bone marrow 2002 11943481
    SIGLEC-L1L
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestiveintestinesmall intestine  highly
     stomach   moderately
    Lymphoid/Immunespleen   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunemacrophage Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two patterns of organization of the signal peptide, which is followed by one V-set domain
  • one transmembrane domain
  • C2-set domains
  • cytoplasmic tail with a putative ITIM and putative SLAM-like tyrosine based motif, or an immunoreceptor tyrosine-based switch motif
  • lacks a conserved arginine residue known to be essential for optimal sialic acid recognition by previously known Siglecs
  • HOMOLOGY
    interspecies homolog to C.elegans F54D8.3
    intraspecies homolog to SIGLEC8
    Homologene
    FAMILY
  • sialic acid-binding immunoglobulin-like lectin family
  • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • negative regulator of signaling in macrophage by functioning as an inhibitory receptor
  • has undergone an additional polymorphic pseudogenization in humans
  • important part of the cell-cell communication system both within an organism and in between organisms such as host and pathogens
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to the tyrosine phosphatases PTPN6 and PTPN11 in a phosphorylation-dependent manner
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in prostate carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveprostate
    Because Siglec-XII can be internalized upon antibody binding, a simultaneous delivery of a toxin attached to the antibody could be a viable approach to future cancer therapy
    ANIMAL & CELL MODELS