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FLASH GENE
Symbol SIDT2 contributors: mct - updated : 08-06-2011
HGNC name SID1 transmembrane family, member 2
HGNC id 24272
Location 11q23.3      Physical location : 117.049.938 - 117.068.161
Synonym symbol(s) CGI-40, FLJ90656, DKFZp686L17253
DNA
TYPE functioning gene
STRUCTURE 18.22 kb     26 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
26 splicing 3919 94.5 832 - 2000 10810093
EXPRESSION
Rna function
  • high SIDTt2 mRNA levels were found in the liver, kidney, as well as brain and intestine.
  • Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver     Homo sapiens
    Nervousbrain     Homo sapiens
    Reproductivemale systemtestis  predominantly
    Urinarykidney     Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 10 potential transmembrane domains
  • two potential tyrosine-based sorting signals (YGSF and YDTL)
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to murine Sidt2
    Homologene
    FAMILY SID1 family
    CATEGORY structural protein , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,lysosome
    text
  • small punctate staining patterns throughout the cytoplasm with predominance in the perinuclear region, and localized in lysosomes
  • basic FUNCTION
  • highly glycosylated lysosomal integral membrane protein that shows tissue-specific expression
  • integral membrane protein of lysosome, putatively functioning as a transporter
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS