| protein
| DCC |
|
NCOR |
|
POU2AF1 and leading to their destabilization and degradation through the ubiquitin-proteosome pathway |
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interacting with SNCAIP (ubiquitylation of SNCAIP) |
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interacting with RBBP8, leading to RBBP8 degradation by the ubiquitin-proteasome pathway |
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interacts with the scaffold protein SH3RF1 to promote JNK activation and apoptosis |
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interact with the JmjC domain of HIF1AN through its substrate-binding domain and to specifically ubiquitinate HIF1A via its RING finger domain |
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interacting with SNCA and binding the brain-enriched E2 ubiquitin-conjugating enzyme UBE2E2 (facilitates mono- and di-ubiquitination of SNCA, promoting aggregation and apoptotic cell death, and playing a critical role in Lewy body formation and Parkinson pathogenesis) |
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could interact with TRB3 (SIAH1 targeted TRB3 for proteasome-dependent degradation)  |
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interacted with, and ubiquitinated HIF1AN |
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interacting with GAPDH (binds SIAH1, forming a complex subsequently promoting translocation of GAPDH from the cytosol to the nucleus and NLS on SIAH1 facilitates the nuclear movement of the complex) (Chepchumba 2010) |
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SIAH1 induces the degradation of Kid (KIF22), a chromokinesin protein implicated in the normal progression of mitosis and meiosis, by the ubiquitin proteasome pathway |
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PRPS1 interacts with the E3 ligase SIAH1 (seven in absentia homolog 1) to induce ubiquitination and degradation of XIAP |
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EEF1D is a SIAH1-interacting protein, and EFF1D functions as a novel negative regulator of SIAH1 |
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RING domain protein SIAH1, but not the homologous SIAH2, is the E3 ubiquitin ligase for ELL2 polyubiquitination and proteasomal degradation |
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GAPDH–SIAH1 interaction is augmented by S-nitrosylation of GAPDH |
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NPM1 physiologically bound to both SIAH1 and GAPDH, disrupting the SIAH1–GAPDH complex in the nucleus in response to nitrosative stress |
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interaction of TNK2 with SIAH1 and the induction of proteasomal degradation of TNK2 by SIAH1 are independent of ACK1 kinase activity |
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SIAH1 and SIAH2 are binding partners of USP19, interaction mediated by a SIAH-consensus binding motif and promoting USP19 ubiquitylation and proteasome-dependent degradation |
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PIN1 regulates SIAH1–mediated HIPK2 ubiquitination and degradation |
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a COPS5/CTNNB1/SIAH1 interaction network that might control CTNNB1 degradation in colorectal cancer cells |
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EXOC3 regulates cytoplasmic translocation of CDKN1B through CDKN1B phosphorylation at Thr157, thereby promoting CDKN1B degradation in the cytoplasm via interaction with COPS5 and SIAH1 and suppressing cell cycle progression |
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MAP3K5 a representative stress kinase, interacts with both GAPDH and SIAH1 and is likely able to phosphorylate Siah1 at specific amino acid residues |
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CDK2 phosphorylation regulates the protein stability of KLF10 by interfering with binding of the E3 ligase SIAH1 |
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ABL1 protected HIPK2 from degradation mediated by the ubiquitin E3 ligase SIAH1 |
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dissociation of the GAPDH/SIAH1 pro-apoptotic complex can block high glucose-induced pericyte apoptosis, widely considered a hallmark feature of Diabetic retinopathy (DR) |
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USP19 is the only deubiquitinase that directly binds to SIAHs(SIAH1, SIAH2) through the substrate binding pocket |
