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FLASH GENE
Symbol SI contributors: mct - updated : 04-09-2018
HGNC name sucrase-isomaltase
HGNC id 10856
Corresponding disease
CSID sucrase-isomaltase deficiency
Location 3q26.1      Physical location : 164.696.686 - 164.796.283
Synonym name
  • oligosaccharide alpha-1,6-glucosidase
  • Synonym symbol(s) MGC131621, MGC131622
    EC.number 3.2.1.10, 3.2.1.48
    DNA
    TYPE functioning gene
    STRUCTURE 99.00 kb     48 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D3S20 /D3S21 - D3S47 - D3S14 , D3S196 - SI - qter
    Authors LDB (99)
    Physical map
    SMC4L1 3q26.1 SMC4 structural maintenance of chromosomes 4-like 1 (yeast) TSBF1 3q26.1 tumor suppressor TSBF1 KPNA4 3q25.33 karyopherin alpha 4 (importin alpha 3) LOC90133 3q26.1 hypothetical protein LOC90133 FLJ22595 3q26.1 hypothetical protein FLJ22595 LOC389172 3 LOC389172 PPM1L 3q26.1 protein phosphatase 1 (formerly 2C)-like B3GALT3 3q25 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 3 CGI-07 3q26.1 CGI-07 protein ADMP 3q26.1 ADMP LOC285214 3q26.1 similar to 60S ribosomal protein L23a LOC131149 3q26.1 similar to otolin-1 SI 3q25.2-q26.2 sucrase-isomaltase SLITRK3 3q26.1 SLIT and NTRK-like family, member 3 BCHE 3q26.1-q26.2 butyrylcholinesterase LOC389173 3 similar to phosphoserine aminotransferase isoform 1 LOC285320 3q26.2 similar to heterochromatin-specific nonhistone protein LOC131055 3q26.2 similar to peptidyl-Pro cis trans isomerase FLJ23049 3q26.2 hypothetical protein FLJ23049 SERPINI2 3q26.1-q26.2 serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 2 FLJ33620 3q26.2 hypothetical protein FLJ33620 PDCD10 3q26.2 programmed cell death 10 SERPINI1 3q26.31 serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1 GOLPH4 3q26 Golgi phosphoprotein 4 LOC389174 3 LOC389174 LOC253820 3q26.2-q26.31 similar to MEGF6 LOC93556 3q26.31 hypothetical protein BC011266 EVI1 3q26 ecotropic viral integration site 1 MDS1 3q21-q26 myelodysplasia syndrome 1 LOC389175 3 similar to ribosomal protein L22
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     intestinesmall intestine   
    Endocrinethyroid    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    a p-type (trefoil) domain
    HOMOLOGY
    Homologene
    FAMILY glycosyl hydrolase 31 family
    CATEGORY enzyme , unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • sucrase-isomaltase, alpha D-glucosidase from intestinal mucosa that hydrolyzes sucrose and isomaltase
  • protein of the small intestine brush-border membrane responsible for catalyzing the hydrolysis of dietary sucrose and some of the products of starch digestion
  • playing an important role in the final stage of carbohydrate digestion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CSID
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS