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FLASH GENE
Symbol SHPRH contributors: mct/npt - updated : 08/11/2008
HGNC name SNF2 histone linker PHD RING helicase
HGNC id 19336
Location 6q24.2      Physical location : 146.205.946 - 146.285.233
Synonym name SNF2, histone-linker, PHD and RING finger domain-containing helicase
Synonym symbol(s) FLJ90837, KIAA2023, RP11-545I5.1, FLJ27258, FLJ37625, FLJ45012, MGC134886, bA545I5.2
EC.number 3.6.1.-, 6.3.2.-,
DNA
TYPE functioning gene
STRUCTURE 79.29 kb     30 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
30 - 7347 193 1687 - Motegi (2006)
30 - 7000 193.4 1659 - Motegi (2006)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary  highly
Lymphoid/Immunethymus   highly
Reproductivefemale systemuteruscervix highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two partial SNF2 domains and 1 each of PHD finger, RING finger, linker histone
  • DEAD helicase domains
  • a nuclear localization signal
  • HOMOLOGY
    interspecies ortholog to yeast Rad5
    Homologene
    FAMILY
  • SNF2/rRAD54 helicase family
  • CATEGORY transcription factor , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,chromatin/chromosome,nucleosome
    basic FUNCTION
  • may be playing a role in chromatin-mediated transcriptional regulation
  • possible candidate for the tumor suppressor gene
  • HLTF and SHPRH suppress mutagenesis in a damage-specific manner
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism
    signaling
    RAD5/SHPRH-dependent pathway is a conserved and fundamental DNA repair mechanism that protects the genome from genotoxic stress
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associates with PCNA, RAD18, and the ubiquitin-conjugating enzyme UBE2N and promotes methyl methanesulfonate (MMS)-induced PCNA polyubiquitination
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS