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FLASH GENE
Symbol SHOC2 contributors: mct/npt - updated : 16-12-2016
HGNC name soc-2 suppressor of clear homolog (C. elegans)
HGNC id 15454
Corresponding disease
NLLAH Noonan-like syndrome with loose anagen hair
Location 10q25      Physical location : 112.679.300 - 112.773.424
Synonym name
  • leucine-rich protein,homolog to C elegans soc2
  • Ras-binding protein Sur-8
  • weakly similar to contains similarity to leucine-rich repeats
  • [C.elegans]
    Synonym symbol(s) SOC2, SUR8, SOC-2, SUR-8, KIAA0862, SIAA0862
    DNA
    TYPE functioning gene
    STRUCTURE 94.12 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC387711 10 LOC387711 LOC390001 10 similar to mitogen-activated protein kinase-activated protein kinase LOC390002 10 similar to B-cell receptor-associated protein 37; repressor of estrogen receptor activity XPNPEP1 10q25.3 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble RNU4P5 10q25.2 RNA, U4 small nuclear pseudogene 5 ADD3 10q24.2-q24.3 adducin 3 (gamma) MXI1 10q25 MAX interacting protein 1 SMNDC1 10q23 survival motor neuron domain containing 1 DUSP5 10q25 dual specificity phosphatase 5 CSPG6 10q25 chondroitin sulfate proteoglycan 6 (bamacan) LOC340699 10q25.3 similar to 1110018J23Rik protein PDCD4 10q24 programmed cell death 4 (neoplastic transformation inhibitor) SHOC2 10q25 soc-2 suppressor of clear homolog (C. elegans) ADRA2A 10q25 adrenergic, alpha-2A-, receptor KIAA1560 10q25.3 glycerol 3-phosphate acyltransferase, mitochondrial TECTB 10q25-q26 tectorin beta LOC390003 10 similar to guanylyl cyclase with kinase-like domain, soluble FACL5 10q25.1-q25.2 fatty-acid-Coenzyme A ligase, long-chain 5 ZDHHC6 10q26.11 zinc finger, DHHC domain containing 6 VTI1A 10q26.11 vesicle transport through interaction with t-SNAREs homolog 1A (yeast) TCF7L2 10q25.3 transcription factor 7-like 2 (T-cell specific, HMG-box) FLJ23556 10q26.11 hypothetical protein FLJ23556 LOC390004 10 similar to peptidylprolyl isomerase E (cyclophilin E) HABP2 10q26.11 hyaluronan binding protein 2 NRAP 10q23-q26 nebulin-related anchoring protein CASP7 10q25.1-q25.2 caspase 7, apoptosis-related cysteine protease FLJ23537 10q26.11 hypothetical protein FLJ23537 DCLRE1A 10q25.1 DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae) FLJ25621 10q26.11 FLJ25621 protein FLJ20147 10q26.11 hypothetical protein FLJ20147 ADRB1 10q24.3 adrenergic, beta-1-, receptor FLJ10188 10q26.11 CTCL tumor antigen L14-2 TDRD1 10q24.1-q25.3 tudor domain containing 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 3962 64 582 - Sieburth (1998)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal lysine-rich region (Cordeddu 2009)
  • composed predominantly of 19 leucine-rich repeats, leucine-rich protein with two YXNX motifs (Sieburth 1998)
  • HOMOLOGY
    interspecies homolog to C.elegans soc2(suppressor of clear (clr-1))
    homolog to murine Shoc2
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • implicated in fibroblast growth receptor signaling
  • may mediate its effects through Ras binding (Sieburth 1998)
  • its function is essential for activation of the MAPK pathway by growth factors (Rodriguez-Viciana 2006)
  • leucine-rich repeat–containing protein that positively modulates RAS-MAPK signal flow (Cordeddu 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Binds K-RAS and N-RAS
  • interacts directly with Ras but not with the Ras(P34G) mutant protein (Sieburth 1998)
  • interacts with ERBB2IP via its LRR domain (Dai 2006)
  • ERBIN inhibits RAS-mediated activation of the extracellular signal-regulated kinase (ERK) by binding to Soc-2 suppressor of clear homolog (SHOC2)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NLLAH
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS