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FLASH GENE

Symbol

SHKBP1

contributors: mct - updated : 03/10/2008

HGNC name	SH3KBP1 binding protein 1
HGNC id	19214

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19q13.2      Physical location : 41.082.756 - 41.097.304
Synonym name	SETA (src homology 3 (SH3)-encoding, expressed in tumorigenic astrocytes) binding protein 1
Synonym symbol(s)	PP203, Sb1

DNA

TYPE	functioning gene
STRUCTURE	14.51 kb     18 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 18 - 2357 - 707 - Liu (2006)

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus       highly Endocrine thyroid       highly Lymphoid/Immune spleen       highly Reproductive female system uterus cervix   highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

Homologene

FAMILY

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular,cytoplasm,organelle,lysosome

basic FUNCTION

may function as a regulator of cathepsin B-mediated apoptosis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interact with cathepsin B (co-localized with cathepsin B in cellular lysosomes)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS